基本説明
Introductory text on receptor pharmacology provides in-depth coverage of the rapidly expanding research area. This third edition features results from recent research on how the structure of receptors determines the interaction between the receptor and the signal transducer. Previous ed.: 2002.
Full Description
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors.
The hallmark of this popular text is the uniting of four major approaches to the study of receptors:
Molecular investigation of receptor structure
Quantitative functional studies of agonists and antagonists
Ligand binding
Signal transduction at the cell membrane
Maintaining the second edition's focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text.
A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.
Contents
Drug-Receptor Interactions: Classical Approaches to the Study of Drug-Receptor Interactions. Molecular Structure of Receptors: Structure and Function 7-TM G-Protein Coupled Receptors. The Structure of Ligand-Gated Ion Channels. Molecular Structure of Receptor Tyrosine Kinases. Ligand-Binding Studies of Receptors: Direct Measurement of Drug Binding to Receptors. Transduction of the Receptor Signal: Receptors Linked to Ion Channels: Mechanisms of Activation and Block. G-Proteins. Signal Transduction through Protein Tyrosine Kinases. Receptors as Pharmaceutical Targets: Receptors as Pharmaceutical Targets.
