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Full Description
The 1990s witnessed the birth and maturing of a field of research centering on the Ca2+ signalling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signalling mechanisms and specific physiological functions of these two messengers in various cellular systems.



