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This book provides a comprehensive understanding of the transformative potential of stem cell therapies for improving skin health and treating debilitating dermatological disorders.
Stem Cell Therapy in Dermatological Disorders delves into the emerging field of stem cell therapy as a revolutionary approach to treating various dermatological conditions. This book provides a comprehensive overview of the science behind stem cell technology, focusing on its applications in skin regeneration, wound healing, and the management of chronic skin diseases. It examines the cellular and molecular mechanisms that make stem cells uniquely suited for dermatological use, exploring their ability to promote tissue repair, modulate inflammation, and restore the skin's structural integrity. This book aims to bridge the gap between experimental research and clinical application, presenting up-to-date findings on the different types of stem cells used in dermatology, including mesenchymal stem cells, induced pluripotent stem cells, and embryonic stem cells. It highlights the role of stem cells in addressing disorders such as atopic dermatitis, psoriasis, vitiligo, and chronic non-healing wounds. Readers will find in-depth discussions on current therapeutic techniques, the challenges of translating preclinical studies to human trials, and the ethical considerations associated with stem cell therapies.
In addition to discussing the state-of-the-art in stem cell-based treatments, the book also casts an eye on the future, identifying gaps in existing knowledge and potential areas for innovation. The authors provide insights into novel delivery systems, genetic engineering advancements, and combinatory approaches that may enhance the efficacy and safety of stem cell therapies in dermatology. This volume serves as an essential resource for dermatologists, researchers, and clinicians seeking to understand the transformative potential of stem cell therapies in improving skin health and treating debilitating dermatological disorders.
Readers will find the book:
Explores the latest breakthroughs in stem cell therapy for skin disorders;
Bridges the gap between basic science and clinical applications;
Discusses mesenchymal stem cells (MSCs), iPSCs, and exosome-based therapies.
Audience
Dermatologists, dermatopathologists, plastic surgeons, medical aestheticians, researchers, clinicians, and biotechnology and pharmaceutical professionals involved in regenerative medicine and aesthetic dermatology.
Contents
Preface xv
1 Fundamentals of Stem Cell Therapy in Disease Prevention 1
Rajarshi Nath, Arijit Das, Shambo Panda, Souvik Biswas and Biplab Debnath
1.1 Introduction to Stem Cell Therapy 2
1.2 Mechanisms of Stem Cell Therapy 4
1.3 Applications of Stem Cell Therapy in Disease Prevention 8
1.4 Challenges and Limitations of Stem Cell Therapy 11
1.5 Future Perspectives and Innovations 14
2 Stem Cell Therapy on Skin: Mechanisms and Recent Advances 19
Koushik Jana, Md. Kabirul Islam Mollah, Gouranga Dutta, Goutam Ghosh and Goutam Rath
2.1 Background and Historical Overview of Stem Cell Therapy 20
2.2 Skin Diseases and Stem Cell Treatment 21
2.3 Types of Stem Cells and Their Mechanism in Skin Diseases 27
2.4 Recent Advancements in Skin Disease Stem Cell Therapy 30
2.5 Challenges and Regulatory Aspects 34
2.6 Conclusion and Future Outlooks 34
3 Stem Cell Therapy: Significant Option for Psoriasis Management 43
Joy Das, Utpal Bhui, Saistha Anjum, Sumel Ashique, Mohammad Muztaba and Sanjay Dey
3.1 Introduction 44
3.2 Advantages of Stem Cell Therapy for Psoriasis 46
3.3 Types of Stem Cell Therapy in Psoriasis 48
3.4 Therapeutic Value of Stem Cell 51
3.5 Challenges in Cost, Availability, and Clinical Application 60
3.6 Regulatory Aspects of Stem Cell Therapy 64
3.7 Conclusion and Future Directions 65
4 Therapeutic Modalities of Stem Cells: Skin Cancer Treatment 79
Dipanjan Karati, Soumi Das and Swarupananda Mukherjee
4.1 Introduction 80
4.2 Stem Cells in Skin Cancer: A Brief Overview 81
4.3 Therapeutic Modalities of Stem Cells in Skin Cancer Treatment 83
4.4 Emerging Trends and Advanced Technologies in Stem Cell Therapy for Skin Cancer 90
4.5 Challenges and Limitations of Stem Cell-Based Therapies 95
4.6 Preclinical and Clinical Studies: Insights and Outcomes 96
4.7 Future Directions and Perspectives 97
4.8 Conclusion 98
5 Therapeutic Advancement of Stem Cell Therapy in Atopic Dermatitis 109
Kishanta Kumar Pradhan, Rojalin Samanta, Reechik Bandyopadhyay, Arnab Seth and Chowdhury Mobaswar Hossain
5.1 Background of Atopic Dermatitis 110
5.2 Stem Cell Biology and Mechanisms 111
5.3 Types and Pathophysiology of AD 120
5.4 Different Stem Cell Application on AD 122
5.5 Challenges and Ethical Considerations 125
5.6 Recent Advancement of Stem Cell Therapy on AD 128
5.7 Clinical Research Updates 130
6 Stem Cell Therapy: A Significant Therapeutic Approach in Wound Healing 141
Richa Dayaramani, Soma Jana, Bratati Bandyopadhyay, Amlan Bishal and Subhashis Debnath
6.1 Introduction 142
6.2 Physiology of Wound-Healing Process 143
6.3 Biology of Stem Cells and their Role in Wound Healing 145
6.4 Stem Cell Therapy for Wound Healing and Histopathological Studies 148
6.5 Stem Cell Delivery Mechanisms for Wound Healing 148
6.6 Clinical Uses of Stem Cell Therapy in Wound Healing 149
6.7 Recent Developments and Technologies in Stem Cell Research for Wound Healing 150
6.8 Challenges in Stem Cell Treatment 151
6.9 Potential Future Applications of Stem Cell-Derived Products in the Use of Stem Cells for Wound Healing 154
6.10 Conclusion 157
7 Stem Cell Therapy: Skin Aging Blocking 163
Dipanjana Ash, Sohini Sen, Sneha Shaw, Ayon Dutta, Leena Kumari and Swarupananda Mukherjee
7.1 Introduction 164
7.2 Stem Cell: An Overview 165
7.3 Mechanisms of SC Action in Skin Regeneration 170
7.4 Preclinical Applications of SC in Skin Aging 173
7.5 Clinical Applications of SC in Skin Aging 175
7.6 Challenges and Considerations 177
7.7 Future Directions and Innovations 181
7.8 Conclusion 182
8 Future Window of Stem Cells in Skin Regeneration and Rejuvenation: Current Status and Future Aspect 195
Vivek Barik, Bramhajit Chatterjee, Snigdha Chatterjee, Swarupananda Mukherjee and Piyali Khamkat
8.1 Introduction 196
8.2 Types of SCs Used in Skin Regeneration and Rejuvenation 198
8.3 Emerging Technologies and Innovations 202
8.4 Challenges in SC-Based Therapies 205
8.5 Future Directions of SCs in Skin Regeneration and Rejuvenation 206
8.6 Current Clinical Trials Updates 208
8.7 Regulatory Challenges for SC-Based Therapies 210
8.8 Conclusion 211
9 Stem Cell Therapy in Dermatology: Challenges and Opportunities 219
Garima Chandak, Sumel Ashique, Shubham Kumar, Narendra Kumar Pandey, Dileep Singh Baghel, Bimlesh Kumar, Saurabh Singh and Omji Porwal
9.1 Introduction 220
9.2 Types of Stem Cells in Dermatology 224
9.3 Mechanisms of Action 225
9.4 Current Applications of Stem Cell Therapy in Dermatology 230
9.5 Advances in Stem Cell Delivery Systems 235
9.6 Challenges in Stem Cell Therapy for Dermatology 238
9.7 Opportunities and Emerging Trends 242
9.8 Preclinical and Clinical Studies 246
9.9 Regulatory and Ethical Considerations 255
9.10 Future Directions 256
9.11 Conclusion 257
10 Clinical Significance and Regulatory Aspects of Stem Cell Therapy 271
Debasmita Paul, Karan Kr. Das, Abhijit Ghosh, Soukat Chandra and Shaileyee Das
10.1 Introduction 272
10.2 Definition and Types of Stem Cells 274
10.3 Mechanisms of Action of Stem Cell Therapy 276
10.4 Future Perspectives 291
10.5 Conclusions and Future Directions 293
11 Translational Research for Dermatological Stem Cell Therapy 301
Mishra Bharti, Khan Anam, Gothalwal Ragini, Jaiswal Prashansa and Kotnis Ashwin
11.1 Introduction 301
11.2 Mechanism of Stem Cell Action in Skin Regeneration and Healing 304
11.3 Current Applications of Stem Cell Therapy in Dermatology 307
11.4 Safety and Challenges in Translating Stem Cell Research to Clinical Practice 310
11.5 Conclusion and Prospects for the Future 312
12 In Vitro and In Vivo Model of Stem Cell Therapy in Dermatological Diseases 321
Sneha Das, Pradip Jana, Mohini Mondal, Mainak Chatterjee and Moitreyee Chattopadhyay
12.1 Introduction 322
12.2 Current and Future Perspectives of SC Therapy in Dermatology by In Vitro and In Vivo Models 325
12.3 In Vitro Models for SC Therapy in Dermatological Diseases 328
12.4 Various Animal Model for In Vivo in Dermatological Diseases 331
12.5 Analytical and Numerical Solutions to the Various Models 334
12.6 Conclusions and Future Directions 335
13 Preclinical and Clinical Trials and Case Studies Involved in Stem Cell Therapy in Dermatological Diseases 341
Rony Mandal, Somali Gorai and Sajal Kumar Jha
13.1 Introduction 342
13.2 Forms of Stem Cell Therapy 343
13.3 Role of Autoimmune System in Dermatological Skin Problem 347
13.4 Therapeutic Value of Stem Cell in Different Allergic Skin Disease 350
13.5 Role of Cutaneous Stem Cells in Regeneration of Different Tissues 352
13.6 Advantages of Stem Cell Therapy for Different Dermatological Diseases 354
13.7 Different In Vivo and In Vitro Models for Preclinical SCT 356
13.8 Preclinical Test Method for Different Skin Disease 360
13.9 FDA-Approved Clinical Phase Trial Drugs for Dermatological Disease 364
13.10 Conclusions and Future Directions 365
References 366
Bibliography 370
Index 371
