Full Description
This volume reviews the experimental data on drug-radiation interactions. Special emphasis is placed on clinically-useful antitumor drugs. Particular reference is made to appropriate timing, concentration and sequencing of drug-radiation combinations. It includes discussions on the relative merits of experimental data derived from animal versus human tumors. This book also presents a section on the potential for new model systems or alternative test procedures for evaluating therapeutic benefits and cytotoxicities. Results of randomized clinical studies are reviewed with emphasis on recent studies involving protocols specifically designed to test the benefits from optimal integration of chemotherapy with radiotherapy. This book is intended for laboratory researchers in the field and clinicians interested in using the combined modality approach. It is also a useful resource for radiologists, oncologists, and all those interested in cancer research.
Contents
Fundamental Concepts Associated with Combining Cytotoxic Drugs and X-Irradiation. Radiation Damage Interaction with Actinomycin D and Adriamycin. Interactions between Bleomycin and X-Irradiation. Interactions between Cyclophosphamide and Radiation. Useful Interactions between 5-Fluorouracil and Radiation in Man: 5-Fluorouracil as a Radio-Sensitizer. Interactions between Microtubule Inhibitors and Ionizing Radiation. Interactions between Mitomycin C and Radiation. Interactions between Nitrosoureas and X-Irradiation. Interactions between Cisplatin and Radiation in Experimental Rodent Tumors and Normal Tissues. Interactions between Platinum Coordination Complexes and Radiation. Experimental Drug-Radiation Interactions in Critical Normal Tissues. In Vitro Drug-Radiation Interactions Using Fractionated X-Irradiation Regimens. Overview of Experimental Investigations of Interactions between Antitumor Drugs and X-Irradiation. Clinical Role of Combined Chemotherapy and Radiotherapy. Overview of Recent Developments and Perspectives.
