Full Description
A simple, effective, and time-proven method of learning the essential concepts of pharmacologyA MUST-READ FOR THE USMLE STEP 2Basic Concepts in Pharmacology: What You Need to Know for Each Study Class, Fifth Edition provides you with a complete framework for studying - and understanding - the fundamental principles of drug actions. This unique resource presents drugs by classes, details exactly what you need to know about each class, and reinforces key concepts and definitions. With Basic Concepts in Pharmacology: What You Need to Know for Each Study Class you will be able to identify your strengths and weaknesses, minimize memorization, streamline your study, and build your confidence. With this innovative text you'll be able to:* Recognize the concepts you truly must know before moving on to other material* Understand the fundamental principles of drug actions* Organize and condense the drug information you must remember* Review key information, which is conveniently presented in boxes, tables, and illustrations* Identify the most important drugs in each classSeven sections specifically designed to simplify the learning process and help you gain an understanding of the most important concepts:* General Principles* Drugs That Affect the Autonomic Nervous System* Drugs That Affect the Cardiovascular System* Drugs That Act on the Central Nervous System* Chemotherapeutic Agents* Drugs That Affect the Endocrine System* Miscellaneous DrugsIf you are in need of a time-saving, stress-reducing approach to learning about drug classes and their mechanisms of action, your search ends here.
Contents
1. Where to StartPart I General Principles2. Receptor TheoryAgonistsEfficacy and PotencyTherapeutic IndexAntagonistsInverse Agonists3. Absorption, Distribution, and ClearanceFirst-Pass EffectHow Drugs Cross MembranesBioavailabilityTotal Body Clearance4. PharmacokineticsVolume of DistributionFirst-Order KineticsZero-Order KineticsSteady-State ConcentrationTime Needed to Reach Steady StateLoading Dose5. Drug Metabolism and Renal EliminationLiver MetabolismRenal ExcretionPart II Drugs That Affect the Autonomic Nervous System6. Review of the Autonomic Nervous SystemWhy Include This Material?Relevant AnatomySynthesis, Storage, Release, and Removal of TransmittersReceptorsGeneral Rules of InnervationPresynaptic Receptors7. Cholinergic AgonistsOrganization of ClassCholinergic AgonistsCholinesterase Inhibitors8. Cholinergic AntagonistsOrganization of ClassMuscarinic AntagonistsGanglionic BlockersNeuromuscular Blockers9. Adrenergic AgonistsOrganization of ClassDirect-Acting AgonistsDopamineIndirect-Acting AgentsCardiovascular Effects of Norepinephrine, Epinephrine, and Isoproterenol10. Adrenergic AntagonistsOrganization of ClassCentral Blockers-Blockers-BlockersMixed - and -BlockersPart III Drugs That Affect the Cardiovascular System11. Antihypertensive DrugsOrganization of ClassDiureticsDrugs That Interfere With the Renin-Angiotensin SystemAngiotensin-Converting Enzyme InhibitorsAngiotensin II Receptor BlockersSelective Aldosterone Receptor AntagonistsDirect Renin Inhibitor (DRI)Calcium Channel BlockersNitratesOther Direct Vasodilators- and -BlockersClonidine12. Drugs Used in Ischemic Heart Disease and Congestive Heart FailureIschemic Heart DiseaseCongestive Heart FailureReduction of Cardiac WorkloadControl of Excessive FluidEnhancement of ContractilityCardiac GlycosidesSympathomimeticsPhosphodiesterase InhibitorsRanolazine13. Antiarrhythmic DrugsOrganization of ClassClass I Drugs (Sodium Channel Blockers)Class II Drugs ( -Blockers)Class III Drugs (Potassium Channel Blockers)Class IV Drugs (Calcium Channel Blockers)Other Antiarrhythmic DrugsDrugs That Increase Heart Rate14. Drugs That Affect BloodOrganization of ClassAntiplatelet AgentsAnticoagulantsThrombolytic DrugsPhosphodiesterase InhibitorsDrugs Used in the Treatment of Anemia15. Lipid-Lowering DrugsOrganization of ClassAdditional Explanation of MechanismsPart IV Drugs That Act on the Central Nervous System16. Drugs Used in DementiaOrganization of ClassCholinesterase InhibitorsNMDA Blocker17. Anxiolytic and Hypnotic DrugsTolerance and DependenceOrganization of ClassBarbituratesBenzodiazepinesBuspironeDrugs for InsomniaBenzodiazepine Receptor AgonistsMelatonin Receptor AgonistOrexin Recptor Antagonist18. Drugs Used in Mood DisordersOrganization of ClassSerotonin-Specific Reuptake InhibitorsSerotonin/Norepinephrine Reuptake InhibitorsHeterocyclics/TCAsMonoamine Oxidase InhibitorsOther AntidepressantsDrugs Used in Bipolar Disorder19. Antipsychotics or NeurolepticsOrganization of ClassTypical Antipsychotics (First Generation)Serotonin-Dopamine Antagonists (Second Generation)Neuroleptic Malignant Syndrome20. Drugs Used in Parkinson DiseaseOrganization of ClassDopamine Replacement TherapyDopamine Agonist TherapyAnticholinergic Therapy21. Antiepileptic DrugsOrganization of ClassImportant Details About the Most Important DrugsOther Drugs to Consider22. Narcotics (Opiates)Organization of ClassActions of Morphine and the Other AgonistsDistinguishing Features of Some AgonistsOpioid AntagonistsOpioid Agonist-Antagonists23. General AnestheticsOrganization of ClassUptake and Distribution of Inhalational AnestheticsElimination of Inhalational AnestheticsPotency of General AnestheticsSpecific Gases and Volatile LiquidsSpecific Intravenous Agents24. Local AnestheticsOrganization of ClassMechanism of ActionSpecial Features About Individual AgentsPart V Chemotherapeutic Agents25. Introduction to ChemotherapyApproach to the AntimicrobialsGeneral Principles of TherapyDefinitionsImportant Concepts to UnderstandClassification of Antimicrobials26. Inhibitors of Cell Wall SynthesisGeneral Features-LactamsPenicillinsCephalosporinsCarbapenemsMonobactams (Aztreonam)Other Inhibitors of Cell Wall SynthesisGlycopeptidesBacitracinFosfomycinDaptomycin27. Protein Synthesis InhibitorsGeneral FeaturesAminoglycosidesTetracyclinesMacrolidesStreptogramins and OxazolidinonesChloramphenicolClindamycin28. Folate AntagonistsMechanism of ActionSelected Features29. Quinolones and Urinary Tract AntisepticsDrugs in This GroupQuinolonesMethenamine30. Drugs Used in Tuberculosis and LeprosyOrganization of ClassIsoniazidRifampinPyrazinamideEthambutolDapsone31. Antifungal DrugsOrganization of ClassAzole AntifungalsPolyene AntifungalsEchinocandinsFungal Protein Inhibitors32. Anthelmintic DrugsOrganization of ClassDrugs Used Against Cestodes and TrematodesDrugs Used Against NematodesDrugs Used Against Filaria33. Antiviral DrugsOrganization of ClassAnti-HIV DrugsDrugs Used in InfluenzaDrugs Used in Hepatitis B and COther Antivirals34. Antiprotozoal DrugsOrganization of ClassMetronidazoleAntimalarial AgentsTherapeutic ConsiderationsSpecial Features35. Anticancer DrugsOrganization of ClassTerminology and General Principles of TherapyAdverse EffectsCytotoxic DrugsAlkylating AgentsAntimetabolitesAntibiotics and Other Natural ProductsAntibodiesOther Cytotoxic DrugsHormonal AgentsSignal Transduction InhibitorsMiscellaneous AgentsPart VI Drugs That Affect the Endocrine System36. Adrenocortical HormonesOrganization of ClassGlucocorticoidsMineralocorticoidsInhibitors of Adrenocorticoid Synthesis37. Sex SteroidsOrganization of ClassEstrogensAntiestrogensProgestinsAntiprogestinsOral ContraceptivesAndrogensAntiandrogensGnRH Agonists and AntagonistsPDE5 Inhibitors38. Thyroid and Parathyroid DrugsOrganization of ClassThyroid Replacement TherapyDrugs That are Thyroid DownersParathyroid Drugs39. Insulin, Glucagon, and Oral Hypoglycemic DrugsOrganization of ClassInsulinsOral Hypoglycemic AgentsPart VII Miscellaneous Drugs40. Histamine and AntihistaminesOrganization of ClassH1 Receptor Antagonists41. Respiratory DrugsOrganization of Class-AgonistsLeukotriene ModifiersMethylxanthinesCholinergic AntagonistsCromolyn and OmalizumabPulmonary HypertensionCystic Fibrosis42. Drugs That Affect the GI TractOrganization of ClassDrugs That Act in the Upper GI TractDrugs That Act in the Lower GI TractInflammatory Bowel Disease43. Nonnarcotic Analgesics and Anti-inflammatory DrugsOrganization of ClassNonsteroidal Anti-Inflammatory DrugsCOX-2 InhibitorsSalicylates, Including AspirinAcetaminophenOther Drugs for ArthritisAntigout AgentsDrugs Used in the Treatment of Headaches44. ImmunosuppressivesOrganization of ClassCalcineurin InhibitorsMycophenolate Mofetil and AzathioprineMonoclonal Antibodies45. Drugs Used in OsteoporosisOrganization of ClassBisphosphonatesDenosumabParathyroid HormoneSelective Estrogen Receptor ModulatorsEstrogensCalcitonin46. Toxicology and PoisoningPrinciples of ToxicologyGeneral Principles in the Treatment of PoisoningSpecific AntidotesIndexNER(01): WOW
