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Full Description
Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states.
Topics discussed include:
Obstructive airway diseases, etiology, pathophysiology, and existing therapeutic options
What constitutes a lipid and how it is broken down to generate biologically active mediators
The role of enzymes in the process of lipid mediator synthesis
The biology of arachidonic acid, platelet-activating factor, and lysophosphatidic acid and the role they play in airway inflammation
Products of arachidonic acid metabolism such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid
Proresolution lipid mediators in inflammatory airway disease conditions
The role of sphingosine and ceramide in inflammatory airway disease
Protein kinases activated by lipid mediators and those that trigger the generation of lipid messengers
The combined input of a panel of international authorities on lipid mediators makes this volume a valuable resource for all those involved in researching, teaching, and studying airway inflammation as well as those involved in drug discovery research.
Punit Srivastava maintains a blog with additional information about the book and his work.
Contents
Obstructive Airway Diseases: Epidemiology, Etiology, and Therapeutic Options. Lipids: Reservoir of Drug Targets. Phospholipase A2 as a Potential Drug Target for Airway Disorders. 5-Lipoxygenase Pathway: A Validated Route to Drug Discovery. Leukotriene Receptor Antagonists and FLAP Inhibitors. EETs and Oxo-ETE in Airway Diseases. The Eosinophil Chemoattractant 5-Oxo-ET. Cyclooxygenases and Prostaglandin Receptors. Proresolution Mediators of Inflammation in Airway Diseases: Resolvins Pave New Directions. Platelet-Activating Factor Antagonist Therapy for Airway Disorders. Lysophosphatidic Acid in Airway Inflammation. Sphingolipids in Airway Inflammation. Protein Kinase C Isozymes and Airway Inflammation. Prospects for PI3 Kinase Signaling Inhibition in Obstructive Airway Diseases. Index.
