Full Description
The gastrointestinal tract is the most important of the three major routes of entry (and clearance) of xenobiotics and biologic entities into the bodies of mammals. As such, it is also the major route for administration of pharmaceuticals to humans. Gastrointestinal Toxicology, Second Edition describes the mechanism for entry and clearance of xenobiotics, as well as the barriers, immunologic and metabolic issues, and functions present in the GI tract.
Appearing in this volume are also considerations of the microbiome and its actions and influence on the function of the GI tract and on the toxicity and pharmacodynamics of ingested substances (including nutrients, toxins, and therapeutics). These fifteen chapters written by experienced experts in the field address methods to evaluate GI function; specifics of GI function and toxicity assessment in canines and minipigs; classes of compounds with their toxicity; species differences; and the toxicity (and promise) of nanoparticles. Those needing to understand the structure, function, and methods of studying the GI tract will find this volume a singular source of reference.
Contents
Preface
Editor
Contributors
Chapter 1 Introduction: The Gastrointestinal (GI) Tract as a Barrier and as an Absorptive and Metabolic Organ
Shayne C. Gad
Chapter 2 Methods for the Analysis of Gastrointestinal Function
Robin C. Guy
Chapter 3 Safety Pharmacology and the GI Tract
Henry I. Jacoby
Chapter 4 Gastrointestinal Tract Development and Its Importance in Toxicology
Alma M. Feldpausch, Joseph V. Rodricks, Rosalind A. Schoof and Brittany A. Weldon
Chapter 5 Gastrointestinal Tract as a Major Route of Pharmaceutical Administration
Robert W. Kapp, Jr.
Chapter 6 Gastrointestinal Function and Toxicology in Canines
Charles B. Spainhour
Chapter 7 Gastrointestinal Function and Toxicology in Minipigs
Maria R. Jones and Alain Stricker-Krongrad
Chapter 8 Absorption of Macromolecules by Mammalian Intestinal Epithelium
Shayne C. Gad
Chapter 9 Peyer's Patch Epithelium: An Imperfect Barrier and Effect of the Microbiome
Gary R. Burleson and Florence G. Burleson
Chapter 10 Alteration of Intestinal Function by Xenobiotic Exposure: Animal Models
Shayne C. Gad
Chapter 11 The Role of the Microbiome on Metabolism, Absorption, and Toxicity of Xenobiotics in the Gastrointestinal Tract
Shayne C. Gad
Chapter 12 Normal and Abnormal Intestinal Absorption by Humans
David W. Hobson and Valerie L. Hobson Balldin
Chapter 13 Classes of Compounds with GI Tract Toxicity
Amy L. Mihalchik and Erica N. Rogers
Chapter 14 Species Differences in GI Toxicity
Shayne C. Gad
Chapter 15 Nanoparticles in the Gastrointestinal Tract
David W. Hobson and Valerie L. Hobson Balldin
Index
