Full Description
Drug Utilization Research (DUR) is an eclectic scientific discipline, integrating descriptive and analytical methods for the quantification, understanding and evaluation of the processes of prescribing, dispensing and consumption of medicines and for the testing of interventions to enhance the quality of these processes. The discipline is closely related and linked mainly to the broader field of pharmacoepidemiology, but also to health outcomes research, pharmacovigilance and health economics.
Drug Utilization Research is a unique, practical guide to the assessment and evaluation of prescribing practices and to interventions to improve the use of medicines in populations. Edited by an international expert team from the International Society for Pharmacoepidemiology (ISPE), DUR is the only title to cover both the methodology and applications of drug utilization research and covers areas such as health policy, specific populations, therapeutics and adherence.
Contents
List of contributors viii
Acknowledgements xiv
About the companion website xix
Part 1 Introduction
1 Introduction to drug utilization research 3
Björn Wettermark, Monique Elseviers, Anna Birna Almarsdóttir, Morten Andersen, Ria Benko, Marion Bennie, Irene Eriksson, Brian Godman, Janet Krska, Elisabetta Poluzzi, Katja Taxis, Robert Vander Stichele, Vera Vlahovic-Palcevski
Part 2 Methodology
2 Study designs in drug utilization research 15
Björn Wettermark, Mirko Di Martino, Monique Elseviers
3 Primary data collection for drug utilization research 29
Tatiana Chama Borges Luz, Evalill Nilsson
4 Secondary data sources for drug utilization research 39
Irene Eriksson, Luisa Ibáñez
5 Classifi cation systems for drugs and diseases 49
Marit Rønning, Stuart McTaggart
6 Measurement units of drug utilization 58
Hege Salvesen Blix
7 Individual-level drug utilization analyses 68
Jesper Hallas, Henrik Støvring, Anton Pottegård
8 Measurement of drug expenditure 77
Sabine Vogler, Jaana E. Martikainen
9 Basic statistical methods in drug utilization research 88
Douglas T. Steinke, Monique Elseviers
10 Visualization of drug utilization data 99
Maria Matuz, Ria Benko, Mikael Hoffmann
11 Multilevel analyses in drug utilization research 116
Juan Merlo
12 Defi ning and developing quality indicators for drug utilization 126
Stephen Campbell, Björn Wettermark, Morten Andersen
13 Qualitative methods in drug utilization research 139
Anna Birna Almarsdóttir, Pia Bastholm Rahmner
Part 3 Applied drug utilization research
Section A Comparative drug utilization research
14 Comparison of drug utilization across different geographical areas 153
Vera Vlahovic-Palcevski, Björn Wettermark, Luisa Ibáñez, Robert Vander Stichele
15 Comparison of drug utilization in different health care settings 160
Sean MacBride-Stewart, Ksenia Zagorodnikova, Irene Langner, Gisbert W. Selke
16 Time-dependent and seasonal variations in drug utilization 173
Eric Van Ganse, Laurent Laforest, Niels Adriaenssens
17 Comparative studies of patient and prescriber characteristics 184
Irene Eriksson, Ulf Bergman, Vera Vlahovic-Palcevski, Mia von Euler
18 Comparative studies of health systems 194
Tatiana Chama Borges Luz, Claudia Garcia Serpa Osorio-de-Castro, Björn Wettermark
Section B Drug utilization and health policy
19 Drug utilization and health policy 203
Brian Godman, Hye Young Kwon, Marion Bennie, Anna Birna Almarsdóttir
20 Managed introduction of new drugs 210
Brian Godman, Roberta Joppi, Marion Bennie, Saira Jan, Björn Wettermark
21 Management of drugs in the health care system 222
Brian Godman, Marion Bennie, Claudia Garcia Serpa Osorio-de-Castro, Vu Thi Thu Huong, Saira Jan
22 The pharmaceutical industry and health policy 231
Richard Torbett, Donald Han, Indranil Bagchi
Section C Drug utilization in specific populations
23 Drug utilization in pregnant women 240
Hedvig Nordeng
24 Drug utilization in the paediatric population 248
Antje Neubert, Katja Taxis, Ian C.K. Wong
25 Drug utilization in older people 259
Katja Taxis, David O'Sullivan, Shane Cullinan, Stephen Byrne
Section D Drug utilization in specific therapeutic areas
26 Drug utilization research in the area of antibiotics 270
Ria Benko, Marion Bennie, Samuel Coenen
27 Drug utilization research in the area of cardiovascular medicines 284
Elisabetta Poluzzi, Maarit Jaana Korhonen
28 Drug utilization research in the area of analgesics and psychotropics 294
Helga Zoëga, Alesha Smith, Nadia Barozzi
29 Drug utilization research in the area of biologicals 302
Carlo Piccinni, Luigi Naldi, Martin Neovius
30 Drug utilization research in the area of cancer drugs 315
Nils Wilking, Thomas Hofmarcher, Ulla Wilking, Bengt Jönsson
Section E Determinants of drug utilization
31 Health system perspectives 328
Paul Spivey, Brian Godman
32 Prescriber perspectives 336
Colin Bradley, Kathleen Holloway, Janet Krska
33 Patient perspectives 347
Janine Traulsen, Nicky Britten, Janet Krska
Section F Adherence and drug utilization research
34 An introduction to adherence research 355
Bernard Vrijens
35 Assessment of medication adherence in field research 361
Monique Elseviers, Bernard Vrijens
36 Assessment of adherence to drug treatment in database research 369
Jean-Pierre Grégoire, Jocelyne Moisan
37 Interventions to improve adherence to drug treatment 381
Marie-Paule Schneider, Jennifer Celio, Yoleen van Camp, Matthias Cavassini
Section G The role of drug utilization within the field of pharmacoepidemiology
38 Drug utilization research and risk management 392
Giampiero Mazzaglia, Peter Mol
39 Drug utilization research and pharmacovigilance 399
Emanuel Raschi, Fabrizio De Ponti
40 Drug utilization research and the regulator's perspective in pharmacovigilance 408
Xavier Kurz, Kevin Blake
41 Drug utilization research and outcomes research 417
Henrik Toft Sørensen, Gianluca Trifi rò
42 Drug utilization research and pharmacoeconomics 425
Cara Usher, Kathleen Bennett, Lorenzo G. Mantovani, Dyfrig Hughes
Section H Assessment and improvement of the quality of medicine use
43 Assessment of quality of prescribing using quality indicators 433
Petra Denig, Flora Haaijer-Ruskamp, Lisa Pont
44 Quality indicators for patient care in pharmacy practice 443
Hanne Herborg
45 Interventions that infl uence prescribing decisions and drug utilization 460
Jens Søndergaard, Dorte Gilså Hansen, Debra Rowett
46 Development, delivery and evaluation of implementation programmes 468
Elizabeth Roughead, Andrew Gilbert
47 Towards a better understanding of prescribingenhancement interventions 477
Frank May
Part 4 Epilogue
48 The many futures of drug utilization research 489
Hubert G.M. Leufkens, Frank May, Nicky Britten
Glossary 492
Index 497
