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Full Description
Frogs from the genus Xenopus have long been used as model organisms in basic and biomedical research. These frogs have helped unlock key fundamental developmental and cellular processes that have led to important scientific breakthroughs and have had practical application in embryology, cancer research and regenerative medicine. Xenopus Development is a vital resource on the biology and development of these key model organisms, and will be a great tool to researchers using these frogs in various disciplines of biological science. Xenopus Development is divided into four sections, the first three highlight key processes in Xenopus development from embryo to metamophosis. These sections focus on the cellular processes, organogenesis and embryo development. The final section highlights novel techniques and approaches being used in Xenopus research.
Providing thorough and detailed coverage, Xenopus Development, will be a timely and welcome volume for those working in cell and molecular biology, genetics, developmental biology and biomedical research.
Provides broad overview of the developmental biology of both Xenopus laevis and Xenopus tropicalis
Explores cellular to systems development in key biomedical model organisms
Timely synthesis of the field of Xenopus biology
Highlights key biomedical and basic biological findings unlocked by Xenopus
Contents
Contributors vii Preface ix
Section I Oocyte and Early Embryo 1
1 Transcription in the Xenopus Oocyte Nucleus 3
Joseph G. Gall
2 RNA Localization during Oogenesis in Xenopus laevis 16
James O. Deshler
3 From Oocyte to Fertilizable Egg: Regulated mRNA Translation and the Control of Maternal Gene Expression 38
Chad E. Cragle & Angus M. MacNicol
4 Polarity of Xenopus Oocytes and Early Embryos 60
Malgorzata Kloc
5 Germ-Cell Specification in Xenopus 75
Mary Lou King
Section II Midblastula Transition, Gastrulation, and Neurulation 101
6 The Xenopus Embryo as a Model System to Study Asymmetric Furrowing in Vertebrate Epithelial Cells 103
Jacek Z. Kubiak, Isabelle Chartrain, & Jean-Pierre Tassan
7 Induction and Differentiation of the Xenopus Ciliated Embryonic Epidermis 112
Marie Cibois, Pierluigi Scerbo, Virginie Thomé, Andrea Pasini, & Laurent Kodjabachian
8 Wnt Signaling during Early Xenopus Development 130
François Fagotto
9 Neural Tube Closure in Xenopus 163
Hitoshi Morita, Makoto Suzuki, & Naoto Ueno
Section III Metamorphosis and Organogenesis 187
10 Primordial Germ Cell Migration 189
Aliaksandr Dzementsei & Tomas Pieler
11 Development of Gonads, Sex Determination, and Sex Reversal in Xenopus 199
Rafa³ P. Piprek & Jacek Z. Kubiak
12 The Xenopus Pronephros: A Kidney Model Making Leaps toward Understanding Tubule Development 215
Rachel K. Miller, Moonsup Lee, & Pierre D. McCrea
13 Development of Neural Tissues in Xenopus laevis 239
William A. Muñoz, Amy K. Sater, & Pierre D. McCrea
14 The Development of the Immune System in Xenopus 264
Louis Du Pasquier
15 Neural Regeneration in Xenopus Tadpoles during Metamorphosis 293
Mauricio Moreno, Karina Tapia, & Juan Larrain
Section IV Novel Techniques and Approaches 309
16 Atomic Force Microscopy Imaging of Xenopus laevis Oocyte Plasma Membrane 311
Francesco Orsini
17 Size Scaling of Subcellular Organelles and Structures in Xenopus laevis and Xenopus tropicalis 325
Lisa J. Edens & Daniel L. Levy
18 A Model for Retinal Regeneration in Xenopus 346
Masasuke Araki
19 The Xenopus Model for Regeneration Research 368
Ying Chen & Gufa Lin
20 Genomics and Genome Engineering in Xenopus 383
Léna Vouillot, Aurore Thélie, Thibault Scalvenzi, & Nicolas Pollet
Index 403
