Full Description
This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Applications of chiroptical spectroscopy to problems in organic stereochemistry, inorganic stereochemistry, and biochemistry and structural biology are also discussed, and each chapter is written by one or more leading authorities with extensive experience in the field.
Contents
Comprehensive Chiroptical Spectroscopy, Volume 2 PREFACE xi
CONTRIBUTORS xiii
PART I A HISTORICAL OVERVIEW 1
1 THE FIRST DECADES AFTER THE DISCOVERY OF CD AND ORD BY AIME COTTON IN 1895 3
Peter Laur
PART II ORGANIC STEREOCHEMISTRY 37
2 SOME INHERENTLY CHIRAL CHROMOPHORES—EMPIRICAL RULES AND QUANTUM CHEMICAL CALCULATIONS 39
Marcin Kwit, Pawel Skowronek, Jacek Gawronski, Jadwiga Frelek, Magdalena Woznica, and Aleksandra Butkiewicz
3 ELECTRONIC CD OF BENZENE AND OTHER AROMATIC CHROMOPHORES FOR DETERMINATION OF ABSOLUTE CONFIGURATION 73
Tibor Kurtan, Sandor Antus, and Gennaro Pescitelli
4 ELECTRONIC CD EXCITON CHIRALITY METHOD: PRINCIPLES AND APPLICATIONS 115
Nobuyuki Harada, Koji Nakanishi, and Nina Berova
5 CD SPECTRA OF CHIRAL EXTENDED p-ELECTRON COMPOUNDS: THEORETICAL DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY AND EXPERIMENTAL VERIFICATION 167
Nobuyuki Harada and Shunsuke Kuwahara
6 ASSIGNMENT OF THE ABSOLUTE CONFIGURATIONS OF NATURAL PRODUCTS BY MEANS OF SOLID-STATE ELECTRONIC CIRCULAR DICHROISM AND QUANTUM MECHANICAL CALCULATIONS 217
Gennaro Pescitelli, Tibor Kurtan, and Karsten Krohn
7 DYNAMIC STEREOCHEMISTRY AND CHIROPTICAL SPECTROSCOPY OF METALLO-ORGANIC COMPOUNDS 251
James W. Canary and Zhaohua Dai
8 CIRCULAR DICHROISM OF DYNAMIC SYSTEMS: SWITCHING MOLECULAR AND SUPRAMOLECULAR CHIRALITY 289
Angela Mammana, Gregory T. Carroll, and Ben L. Feringa
9 ELECTRONIC CIRCULAR DICHROISM OF SUPRAMOLECULAR SYSTEMS 317
Cheng Yang and Yoshihisa Inoue
10 THE ONLINE STEREOCHEMICAL ANALYSIS OF CHIRAL COMPOUNDS BY HPLC-ECD COUPLING IN COMBINATION WITH QUANTUM-CHEMICAL CALCULATIONS 355
Gerhard Bringmann, Daniel Gotz, and Torsten Bruhn
11 DETERMINATION OF THE STRUCTURES OF CHIRAL NATURAL PRODUCTS USING VIBRATIONAL CIRCULAR DICHROISM 387
Prasad L. Polavarapu
12 DETERMINATION OF MOLECULAR ABSOLUTE CONFIGURATION: GUIDELINES FOR SELECTING A SUITABLE CHIROPTICAL APPROACH 421
Stefano Superchi, Carlo Rosini, Giuseppe Mazzeo, and Egidio Giorgio
PART III INORGANIC STEREOCHEMISTRY 449
13 APPLICATIONS OF ELECTRONIC CIRCULAR DICHROISM TO INORGANIC STEREOCHEMISTRY 451
Sumio Kaizaki
PART IV BIOMOLECULES 473
14 ELECTRONIC CIRCULAR DICHROISM OF PROTEINS 475
Robert W. Woody
15 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDES 499
Claudio Toniolo, Fernando Formaggio, and Robert W. Woody
16 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDOMIMETICS 545
Claudio Toniolo and Fernando Formaggio
17 CIRCULAR DICHROISM SPECTROSCOPY OF NUCLEIC ACIDS 575
Jaroslav Kypr, Iva Kejnovska, Klara Bednarova, and Michaela Vorlickova
18 ELECTRONIC CIRCULAR DICHROISM OF PEPTIDE NUCLEIC ACIDS AND THEIR ANALOGUES 587
Roberto Corradini, Tullia Tedeschi, Stefano Sforza, and Rosangela Marchelli
19 CIRCULAR DICHROISM OF PROTEIN-NUCLEIC ACID INTERACTIONS 615
Donald M. Gray
20 DRUG AND NATURAL PRODUCT BINDING TO NUCLEIC ACIDS ANALYZED BY ELECTRONIC CIRCULAR DICHROISM 635
George A. Ellestad
21 PROBING HSA AND AGP DRUG-BINDING SITES BY ELECTRONIC CIRCULAR DICHROISM 665
Miklos Simonyi
22 CONFORMATIONAL STUDIES OF BIOPOLYMERS, PEPTIDES, PROTEINS, AND NUCLEIC ACIDS. A ROLE FOR VIBRATIONAL CIRCULAR DICHROISM 707
Timothy A. Keiderling and Ahmed Lakhani
23 STRUCTURE AND BEHAVIOR OF BIOMOLECULES FROM RAMAN OPTICAL ACTIVITY 759
Laurence D. Barron and Lutz Hecht
24 OPTICAL ROTATION, ELECTRONIC CIRCULAR DICHROISM, AND VIBRATIONAL CIRCULAR DICHROISM OF CARBOHYDRATES AND GLYCOCONJUGATES 795
Tohru Taniguchi and Kenji Monde
25 ELECTRONIC CIRCULAR DICHROISM IN DRUG DISCOVERY 819
Carlo Bertucci and Marco Pistolozzi
INDEX 843
