Full Description
Fifty million people worldwide have epilepsy and yet up to 35% of patients experience seizures that are resistant to anti-epileptic drugs. Patients with medication-resistant epilepsy have increased risks of premature death, psychosocial dysfunction and a reduced quality of life. This key resource delivers guidance for all clinicians involved in caring for patients with medication-resistant epilepsy in order to reduce these risks. Covering the epidemiology, biology, causes and potential treatments for medication-resistant epilepsy, this definitive and focused text reviews the clinical care needs of patients. Guidance is practical and includes treatment for specialized groups including pediatric patients and those with psychiatric comorbidities. Several promising non-pharmacologic interventions available for patients, such as surgery, neuromodulation diet therapy and botanical treatment are explored in detail. Leading international figures from a range of disciplines bring their expertise together holistically in this essential manual.
Contents
1. The natural history of epilspy Byugin Lee and Sung-Eun Kim; 2. Challenges in identifying medication-resistant epilepsy Martin J. Brodie and Pauls Auce; 3. International league against epilepsy's definition in medication-resistant epilepsy Colin B. Josephson and Samuel Wiebe; 4. The economic impact of medication-resistant epilepsy Charles E. Begley and Shin Jeong; 5. Social consequences of medication-resistant epilepsy Amy Crepeau and Joesph I. Sirven; 6. Morality and morbidity of medication-resistant epilepsy Nuria Lacuey and Samden D. Lhatoo; 7. Models for medication-resistant epilepsy Raman Sankar; 8. Neurobiology of medication-resistant epilepsy Jerome Engel Jr; 9. Genetic causes of medication-resistant epilepsy Thomas N. Ferraro, Bradford D. Fischer and Russel J. Buono; 10. Malformation of cortical development as causes of medication-resistant epilepsy Ruben Kuzniecky; 11. Hippocampal sclerosis as a cause of medication-resistant epilepsy Fahmida Amin Chowdhury, Beate Diehl and Maria Thom; 12. Autoimmune causes of medication-resistant epilepsy Anteneh M. Feyissa and Jeffrey W. Britton; 13. Medication-resistant epilepsy syndromes in children Elia M. Pestana Knight and Elaine Wyllie; 14. Medication-resistant epilepsy in adults Martin Holtkamp and Felix Benninger; 15. Approach to the treatment of medication-resistant epilepsy John Stern; 16. Pharmacotherapy for medication-resistant epilepsy Graham A. Powell and Anththony G. Marson; 17. Reproductive health for women with medication-resistant epilepsy Jiyeon Yoo and Cynthia Harden; 18. Resective medication-resistant epilepsy surgery Barbara C. Jobst and Krzyszof A. Bujarski; 19. Ablative surgery for medication-resistant epilepsy Christian Hoelscher, Kofi-Buaku Atsina, Chengyuan Wu and Ashwini Sharan; 20.1. Vagus and trigeminal nerve stimulation treatment of medication-resistant epilepsy George Nune and Christianne Heck; 20.2. Electrical stimulation of the anterior nucleus of the thalamus for medication-resistant epilepsy Mohamed Z. Koubeissi and Amr Ewida; 20.3. Responsive neurostimulation of the brain for medication-resistant epilepsy Ritu Kapur and Martha J. Morrell; 20.4. Stimulation treatments for medication-resistant epilepsy: transcranial magnetic stimulation Lara M. Schrader; 21. Diet therapy for medication-resistant epilepsy Eric H. Kossoff and Daniel B. Lowenstein; 22. Botanical treatments for medication-resistant epilepsy Steven C. Schachter; 23. Psychiatric comorbidities in medication-resistant epilepsy Andres M. Kanner.
