Full Description
Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.
Contents
List of contributors; Preface; 1. The genetic programs regulating embryonic lung development and induced pluripotent stem cell differentiation Finn Hawkins, Scott A Rankin, Darrell N. Kotton and Aaron M. Zorn; 2. Early development of the mammalian lung-branching morphogenesis Kathleen M. Stewart and Edward E. Morrisey; 3. Pulmonary vascular development Timothy D. Le Cras and Marlene Rabinovitch; 4. Transcriptional mechanisms regulating pulmonary epithelial maturation: a systems biology approach Jeffrey A. Whitsett and Yan Xu; 5. Environmental effects on lung morphogenesis and function: tobacco products, combustion products and other sources of pollution Cindy T. McEvoy and Eliot R. Spindel; 6. Congenital malformations of the lung Susan E. Wert and Kathryn A. Wikenheiser-Brokamp; 7. Lung structure at preterm and term birth Jason C. Woods and Johannes C. Schittny; 8. Surfactant during lung development Timothy E. Weaver, Lawrence M. Nogee and Alan Jobe; 9. Initiation of breathing at birth Arjan te Pas and Stuart Hooper; 10. Perinatal modifiers of lung structure and function Suhas G. Kallapur and Sailesh Kotecha; 11. Chronic neonatal lung injury and care strategies to decrease injury Robert P. Jankov and A. Keith Tanswel; 12. Apnea and control of breathing Christopher C. Stryker, Andrew Dylag and Richard J. Martin; 13 Alveolarization into adulthood Manjith Narayanan; 14. Physiologic assessment of lung growth and development throughout infancy and childhood Anne-Marie Gibson, Sarath Ranganathan and Lex W. Doyle; 15. Perinatal disruptions of lung development: mechanisms and implications for chronic lung diseases Michael A. O'Reilly; 16. Lung growth through the 'life course' and predictors and determinants of chronic respiratory disorders Fernando D. Martinez; 17. The lung structure maintenance program: sustaining lung structure during adulthood and implications for COPD risk Norbert F. Voelkel and Masahiro Sakagami; Index.
