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Full Description
This volume provides a comprehensive overview of experimental models of neuropathic pain and state-of-the-art strategies for the assessment of pain and its associated behavioral and functional outcomes. The book is organized into two complementary parts. Part One focuses on experimental models that, despite their diverse etiologies, converge on a shared neuropathic substrate, ranging from the spared nerve injury (SNI) and FRICT-ION (Foramen Rotundum Inflammatory Constriction Trigeminal InfraOrbital Nerve) models to central traumatic neuropathies and systemic conditions such as diabetic and toxin-induced neuropathies. Part Two is dedicated to pain-related manifestations, with particular emphasis on endophenotypic outcomes, ultrasonic vocalizations, burrowing behavior, anxiety- and depressive-like phenotypes and executive function. In keeping with the tradition of the Neuromethods series, chapters include the kind of detail and key advice from the specialists needed to get successful results in the researchers' laboratories.
Thorough and practical, Translational Research Methods for Neuropathic Pain is a valuable resource for all researchers looking to learn more about this important and developing field.
Contents
The Spared Nerve Injury in the Context of Neuropathic Pain Models: A Step-by-Step Guide.- FRICT-ION: Simple and Reliable Trigeminal Nerve Model of Chronic Craniofacial Neuropathic Pain.- Traumatic Spinal Cord Injury as a Model for Central Neuropathic Pain.- Animal Models for Neuropathic Pain Research in Type 1 and Type 2 Diabetes.- Animal Models of Chemotherapy-Induced Neuropathy: Nociceptive Behavioral Assessment, Metabolic, and Functional Evaluation of the Central Nervous System of Paclitaxel-Injected Rats.- Incisional Model of Post-Operative Pain in Rodents.- Rodent Models of Complex Regional Pain Syndrome Type I (CRPS-I).- Arthritis Murine Models for the Study of Inflammation and Pain.- Investigating Sex-Specific Manifestations in Models of Pain.- Individual Differences using Social Interactions Testing: A Modified Resident-Intruder Test for Measuring Social Behaviors in Rats with Neuropathic Injury.- Ultrasonic Vocalizations in the Context of Rodent Chronic Pain Research: A Protocol.- Identifying the Placebo and Nocebo Responders: Two Methods for Eliciting Placebo Analgesia or Nocebo Hyperalgesia in Rats with a Neuropathic Injury.- Burrowing Behavior as a Pain-Behavioral Readout in Rodent Pain Models.- Racing Against Time: A Practical guide to Study the Temporal Dynamics of Anxiety and Depression in Chronic Pain.- Executive Functions in Chronic Pain Models.- Corticostriatal Connectivity and Its Application to Study Neuropathic Pain-Related Impairments of Cognitive Processes.- Assessing Pain and Related Behaviors in the PhenoWorld.
