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Full Description
This volume bridges the gap between foundational principles and cutting-edge applications used in the evolving field of intrathecal drug delivery. The chapters in this book are organized into four parts: Part One explored the history of neuraxial therapy and the fundamental principles of neuroanatomy, cerebrospinal fluid physiology, and pharmacokinetics. Part Two looks at the transitions from theory to practice, detailing the established clinical applications and surgical techniques for chronic pain, spasticity, CNS infections, and oncology. Parts Three and Four delve into the application of novel therapeutics for neurodegenerative and leptomeningeal diseases, the design of advanced formulations such as nanoemulsions, and an examination of the challenges and emerging solutions that will define the next generation of intrathecal drug delivery systems. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and comprehensive, Intrathecal Drug Delivery is a valuable tool for researchers at all levels, from medical and graduate students to residents and postdoctoral fellows, who are interesting in learning more about this developing and important field.
Contents
Foundations and History of Intrathecal Drug Delivery.- Factors Affecting the Distribution of Intrathecally Administered Drugs.- Implantable Systems for CNS Drug Delivery: Passive Reservoirs and Active Infusion Pumps.- Implantation and Explanation of Intrathecal Drug Delivery Systems: Surgical Technique and Complications.- Intrathecal Drug Delivery for Chronic Pain.- Spasticity and Intrathercal Baclofen Therapy.- Intrathecal Therapy for CNS Infections.- Classic Intrathecal Therapy in Oncology.- Modern Intrathecal Therapy in Oncology.- Intrathecal Therapies for Neurodegenerative Diseases.- Intrathecal Delivery for Leptomeningeal Disease.- Design, Preparation, and Optimization of mRNA Nanoemulsions for CNS Delivery.- The New Wave of Intrathecal Therapies and Related Challenges in Intrathecal Delivery Systems.- Evolving Solutions for the Next Generation of Intrathecal Drug Delivery Systems.- Emerging Solutions for Future Generations of Intrathecal Drug Delivery Systems.- Sustained Intrathecal Drug Delivery Through Nanoporous Isometric Membranas: A Comprehensive In-Silico Evaluation.- Pumpless Implantable Device for Intrathecal Pseudodelivery of Drugs: Feasibility of Implanting a Prototype for Human-Use in a Porcine Model.
