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Full Description
This volume focuses on translational models of pediatric brain cancers that are critical to understanding tumor formation, tumor progression, and response to treatment. These models are particularly important for drug screens and preclinical testing of novel treatment approaches involving chemotherapy, radiation, and immunotherapy. The chapters in this book cover a variety of the latest technologies used to investigate the molecular backbone of pediatric brain tumors. These new diagnostic tools include tumor characterization from liquid biopsy; capturing the local heterogeneity of a single tumor through spatial genomics; and deciphering the unique epigenetic traits of pediatric brain tumors by profiling tumor methylome and post-translational histone modifications. Some chapters also describe the latest experimental tools designed to explore new therapeutic strategies and optimize current treatments. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and thorough, Translational Research Methods for Pediatric Brain Tumors is a valuable resource for clinicians and researchers who want to learn more about experimental pediatric neuro-oncology and help guide the field toward a brighter future.
Contents
Single-Cell Multi-Omics Analyses of Medulloblastoma.- Derivation of Primary Cell Lines from Patient Tumor Samples for In Vitro and In Vivo Studies of Malignant Gliomas.- In Vivo Murine Model for Oncolytic Viral Therapy for Malignant Glioma.- A Method for Circulating Tumor DNA Sequencing Using Cerebrospinal Fluid in Pediatric Central Nervous System Tumors.- Modeling of Proton Radiotherapy Optimization for Pediatric Brain Tumors.- In Vitro Analysis of Cell Cycle Exit of Cerebellar Granule Cell Progenitors.- Using the RCAS/tv-a System and Cre/loxP Recombination to Establish a Primary Mouse Model of Diffuse Midline Glioma.- Preclinical Models for Assessing the Impact of Cranial Irradiation on Executive Function.- A Rapid, Reliable, and Reproducible Cisterna Magna Injection Approach for the Treatment of Leptomeningeal Metastatic Brain Tumors.- In Vivo Mouse Models of Myc-Driven Medulloblastoma.- In Vivo Model of Sonic Hedgehog Medulloblastoma by Postnatal Electroporation.- Techniques for Syngeneic Allograft Injections in Mice for Establishment of Pediatric Brain Tumor Models.- Developing a Zebrafish Xenograft Model of Diffuse Midline Glioma.
