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Full Description
This fully updated second edition provides a variety of procedures for synthetically producing peptides and their derivatives, ensuring the kind of precision that is important for successful synthesis. Chapters explore techniques relevant to drugs and vaccines are explored, such as conjugation and condensation methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Peptide Synthesis: Methods and Protocols, Second Edition aims to be comprehensive guide for researchers in the field.
Contents
Total Synthesis of N-hydroxy cyclic peptide: Talarolide A.- Synthesis of Bicyclic Peptides Using Cyanopyridine-Aminothiol Click Chemistry.- Preparation of Peptide C-Terminal Salicylaldehyde Ester Surrogates via a Hydrazide-Based Oxidation and Phenolysis Strategy.- Novel amino-Li resin for water-based solid-phase peptide synthesis.- Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow.- Solid Phase Synthesis of Peptides with Methyl and Larger Substituents on Backbone Amide Nitrogens via On-Resin Incorporation of the Substituents.- Liquid-Phase Peptide Synthesis Enabled by Electrochemical Amide Bond Formation.- Development of the efficient preparation method for thermoresponsive elastin-like peptides using liquid-phase synthesis combined with fragment condensation strategy.- Diol as a New Pantetheine Surrogate for Chemoenzymatic Synthesis of Cyclic Peptides via Non-Ribosomal Peptide Cyclases.- Advancements in Micro-Bioreactor Technology: High-Throughput Cultivation and Peptide Profiling in Microbial Research.- Solution phase peptide synthesis: the case of biphalin.- A Step-by-Step Guide for Biosynthesis of Recombinant Fusion Antimicrobial Peptide and Release of the Active Peptide from Its Fusion Partner by Formic Acid Cleavage.- Solid-phase synthesis of well-defined defect lysine dendrimers.- Tips and Tricks in Reversed-Phase Flash Chromatography for Peptide Purification.- Synthesis of Caged Aminoluciferin Peptides.- Synthesis of hybrid peptide-based materials.- Synthesis of poly(amino acid)s using ring opening polymerization.- Synthesis of Sulfonopeptides.- Synthesis of Phosphonopeptides.- Inverse Peptide Synthesis Using Transient Protected Amino Acids.- Synthesis of Polymyxin-Inspired Peptidomimetics.- Optimising the synthesis of Desotamides and related cyclic antimicrobial peptides.- Photolabile Linkers for Solid-Phase Synthesis of Oligosaccharides.- Ultra-Efficient Solid Phase Peptide Synthesis.- Automated synthesis and purification of hydrophobic peptides.
