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This book explores the intricate processes of calcium regulation in the human body—both essential and harmful. From bone and dental mineralization to vascular and soft tissue calcification, this book bridges molecular biology, genetics, and modern AI technologies. It highlights key pathways, diagnostic advancements, and future therapeutic strategies. Ideal for medical professionals, researchers, and biomedical engineers, this comprehensive resource offers cutting-edge insights into calcification disorders and their management, uniting foundational science with innovation in imaging, modeling, and robotic-assisted interventions.