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Full Description
Vegetables and fruits are an important part of the diet, and they provide nutrition and have several health benefits. Cucurbitacins are tetracyclic triterpenoid compounds mainly distributed in the Cucurbitaceae family. Cucurbitacins are bitter compounds produced in plants as defense chemicals and they protect plants from herbivores, insects, and parasites. Cucurbitacin-containing plants are making an important part of the human diet in the form of vegetables and fruits. Plants containing cucurbitacins have a great role in disease prevention and treatment, and traditionally they are used for the treatment of infections, cancer, diabetes, and heart and liver diseases. The book "Bioactive Cucurbitacins: Therapeutic Benefits, Toxicity, and Analysis" provides an important guideline for the extraction, isolation, identification, and characterization of bioactive cucurbitacins present in vegetables and fruits. This book emphasizes recent preclinical and clinical studies on cucurbitacins role as a lead molecule for the prevention and treatment of various types of cancers. It also encompasses the role of cucurbitacins in the prevention of treatment of various human infection, metabolic syndrome, and their role as antioxidants and anti-inflammatory agents. This book also addresses the oral bioavailability issues and the role of nanotechnology in solving them. The book summarizes the current state of knowledge in the key research areas and provides ideas for future scientific research to identify lead molecules "cucurbitacins" from vegetables and fruits and to use them in drug discovery and development.
Key Features
• Provides a detailed overview of different cucurbitacins found in vegetables and fruits, chemistry, extraction, isolation, and identification methods.
• Describes their health benefits, toxicity, and nutritional importance.
• Discuss the role of cucurbitacins in treatment of various types of cancers.
• Describes the applicability of sophisticated analytical techniques like HPLC, LC-MS, and HPTLC for analysis of cucurbitacins.
• Emphasizes the use of nanotechnology in improving oral bioavailability of cucurbitacins.
Contents
Preface. Series Preface. List of Contributors. About the Authors/Editors. Section I: Sources, Extraction, Isolation, and Characterization of Cucurbitacins. Chapter 01 Sources and Importance of Cucurbitacins: An Overview. Chapter 02 An Insight into the Chemistry of Cucurbitacins. Chapter 03 Cucurbitacins Extraction: Classical and Advanced Methods. Chapter 04 Isolation and Purification of Cucurbitacins. Chapter 05 Role of spectroscopic techniques in the characterization of cucurbitacins. Section II: Health Benefits and Toxicity of Cucurbitacins. Chapter 06 Anticancer activity of cucurbitacins: in-vitro evidence. Chapter 07 Anticancer activity of Cucurbitacins: in vivo evidence. Chapter 08 Cucurbitacins as potential anticancer therapeutics: evidence from clinical trials and patents. Chapter 09 Role of Cucurbitacin's in the Treatment of Metabolic Syndrome. Chapter 10 Cucurbitacins in the Treatment of Infections. Chapter 11 Antioxidant and Anti-inflammatory Activities of Cucurbitacins. Chapter 12 Cucurbitacin's Toxicity in Humans. Section III: Biopharmaceutical and Analytical Aspects of Cucurbitacins. Chapter 13 Pharmacokinetics and Therapeutic Potential of Cucurbitacins. Chapter 14 Role of Nanotechnology in Improving Bioavailability of Cucurbitacins. Chapter 15 Role of Chromatography in the Analysis of Cucurbitacins. Index.
