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Full Description
Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects joints and bones. Disease modifying anti-rheumatic drugs, biologics and NSAIDs are mostly acclaimed for symptomatic relief but these may have adverse outcomes. Extensive research has been conducted to find alternate and safe treatment options for RA. Phytochemicals in the Management of Rheumatoid Arthritis examines advanced knowledge about pathogenesis, diagnosis, and conventional treatment of RA, application of phytochemicals in the management and prophylaxis of RA through modulation of molecular targets such as matrix metalloproteinases, nuclear factor kappa B, arachidonic acid, RANKL and JAK/STAT.
This book contains research on the mechanisms of action, dosage, and molecular pathways affected by phytochemicals to treat RA, and emphasizes the targeted-drug delivery and novel dosage forms of phytochemicals to improve therapeutic efficacy and abate adverse effects. Additionally, it provides information on clinical studies and the use of photodynamic therapy for the management of RA. It will equip the post-graduate student, health professionals, practitioners, pharmaceutical researchers and biomedical scientists with valuable evidence about the anti-arthritic foods, nutrients, and phytochemicals required for treating RA.
Contents
Section A
Chapter 1: Introduction to chemistry of phytochemicals
Alam Zeb
Chapter 2: Introduction to Rheumatoid arthritis
Mehak Fatima, Ammara Saleem, Justyna Wozniak, Muhammad Furqan Akhtar
Chapter 3: Current pharmacotherapy for Rheumatoid arthritis
Mehak Fatima, Ammara Saleem, Aisha Mobashar, Muhammad Furqan Akhtar
Chapter 4: Combination therapy and dual inhibition of signaling pathways in Rheumatoid arthritis
Tanzeela Awan, Uzma Saher, Justyna Wozniak, Ayesha Fatima, Ammara Saleem
Section B
Chapter 5: Phytochemicals targeting Nuclear factor kappa B and matrix metalloproteinases pathways to treat Rheumatoid arthritis
Hamna Mehmood, Ammara Saleem, Aisha Mobashar, Muhammad Furqan Akhtar, Justyna Wozniak, Joham Javed
Chapter 6: Phytochemicals targeting arachidonic acid pathway to treat Rheumatoid arthritis
Aisha Shehzad, Aqsa Mushtaq , Hafiza Sidra Yaseen, Ammara Saleem
Chapter 7: Phytochemicals targeting JAK/STAT pathway to treat Rheumatoid arthritis
Sara Zahid, Sampath Chinnam, Sana Kashan, Ammara Saleem
Chapter 8: Phytochemicals targeting PI3K/Akt/mTOR signaling pathway to treat Rheumatoid arthritis
Ramla Shabbir, Rukhsar Imran, Shaneel Kousar, Yusuf Tatur, Ammara Saleem
Chapter 9: Phytochemicals targeting transforming growth factor (TGF)-β and Inducible nitric oxide synthase to treat Rheumatoid arthritis
Humaira Gul, Rida Siddique, Muntaha Maqbool, Noor-ul-Eman, Atika Afzal, Faraza Javaid, Yusuf Tatur, Ammara Saleem
Chapter 10: Phytochemicals targeting Vascular endothelial growth factor (VEGF) and RANKL pathway in the treatment of Rheumatoid arthritis
Rida Siddique, Muhammad Asim Shehzad, Rabia Arshad, Ammara Saleem
Chapter 11: Clinical studies about phytomedicines for the management of Rheumatoid arthritis
Atika Afzal, Ayesha Mahmood, Shaneel Kousar, Sajid Ali, Ammara Saleem
Section C
Chapter 12: Phytochemicals as nutraceuticals in the management of Rheumatoid arthritis
Shakila Sabir, Muhammad Naeem, Ammara Saleem, Ghulam Md Ashraf, Muhammad Furqan Akhtar
Chapter 13: Adverse effects of phytochemicals used to treat Rheumatoid arthritis
Shakila Sabir, Muhammad Ejaz-ul-Haq, Ammara Saleem, Syed Haroon Khalid, Muhammad Furqan Akhtar
Section D
Chapter 14: Novel pharmaceutical dosage forms of Phytochemicals for the treatment of Rheumatoid arthritis
Samia Gul Niazi, Mahdia Arshad, Chanda Javed, Shahida Shaeen, Anil Ahsan, Muhammad Furqan Akhtar, Ammara Saleem
Chapter 15: Photodynamic therapy using photoactive phytochemicals
Maria Tahir, Ammara Saleem, Qadeer Ahmad, Muhammad Furqan Akhtar, Mirza Muhammad Faran Ashraf Baig, Muhammad Imran Khan
Chapter 16: Pharmaceutical and regulatory considerations, and future prospective of Phytomedicines and nutraceuticals
Ejaz Basheer, Shahid Rasool, Muhammad Talha, Muhammad Najeeb Ullah, Ammara Saleem, Mhammad Furqan Akhtar
