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Full Description
The Art and Science of Dermal Formulation Development is a comprehensive guide to the theory and practice of transdermal and topical formulation development, covering preclinical studies, evaluation, and regulatory approval. It enables the reader to understand the opportunities and challenges in developing products and how risks can be mitigated. Over the last 25 years, expertise in this area has declined whilst drug delivery systems for other administration routes have developed significantly. The advantages offered by transdermal and topical drug delivery remain compelling for sectors including the pharmaceutical industry, personal care, and cosmetics. This text addresses the dearth of expertise and discusses how skin can be a route of delivery and the processes in formulation development, but how such an application is very different to that used for oral, IV, and other administration routes.
Key Features:
Presents a practical guide for both industry and academia
Focuses on and draws together the fundamental principles behind transdermal and topical drug delivery
Illustrates the practicalities of formulation design using key case studies
Gives an understanding of the skin as a route of delivery and how formulation development for such application differs from that for other administration routes
Contents
Chapter 1: Structure and Function of Human Skin. Chapter 2: Theoretical Aspects of Transdermal and Topical Drug Delivery. Chapter 3: Chemical Modulation of Topical and Transdermal Permeation. Chapter 4: Physical and Technological Modulation of Topical and Transdermal Drug Delivery. Chapter 5: Topical and Transdermal Formulation Development.; Chapter 6: Performance Testing. Chapter 7: Process Development Considerations for Topical and Transdermal Formulations.
