Full Description
Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins.
Key Features
Describes the genetic polymorphism and its various types
Discusses the role of genetic polymorphisms in modulating the risk of various human diseases
Explores various molecular techniques used for detecting GPs
Characterizes the role of SNPs in modulating the susceptibility of human diseases
Provides a genetic basis for individual variations in response to therapeutics
Contents
Table of Contents
1 Genetic Polymorphisms - Classification, Structure, Detection and Function
2 Clinical relevance of Pharmacogenomics a road to personalized medicine
3 Role of SNPs in diabetes susceptibility
4 Role of Single nucleotide polymorphisms in Asthma
5 Xenobiotic Gene polymorphism and their role in cancers
6 Association of MMP gene polymorphisms with cancer risk
7 Vitamin D receptor polymorphisms and diseases
8 Fatty Acid Metabolism Gene polymorphism in disease/cancer Susceptibility
9 Single Nucleotide Polymorphisms and Parkinson's Disease Susceptibility
10 Genetic Polymorphisms, role in drug metabolism and effect on Clinical Pharmacy
11 Role of Genetic polymorphisms in chronic inflammatory diseases
12 Single nucleotide polymorphism related computational-resources part I: Databases
13 Single nucleotide polymorphism related computational-resources part I: Alogrithms
14 Role of single nucleotide polymorphisms (SNPs) in common migraine
15 Role of Vitamin D SNPs in Cancer Susceptibility
16 Role of Genetic Polymorphisms in lipid metabolism pathways in modulating cancer promotion
17 Prostate cancer and genetic polymorphism
18 Role of Single Nucleotide Polymorphism of Cytochrome P450 Genes in Cancer Susceptibility
19 Role of Single Nucleotide Polymorphisms of Inflammatory molecules in susceptibility to Cardiovascular diseases (CVDs)
20 Role of Genetic Polymorphisms in the Etiopathogenesis of Esophageal Cancer
21 Cytokine polymorphism and their role in cancers
22 Gastric Cancer and genetic polymorphism in modulating the susceptibility
23 Cytokine Gene Polymorphisms & their Role in Autoimmune Diseases
24 Genomic disturbances associated with penile cancer and novel therapies
25 Role of Genetic Polymorphisms in Gastric Cancer Susceptibility
