Full Description
Approximately one in twenty men have sperm counts low enough to impair fertility but little progress has been made in answering fundamental questions in andrology or in developing new diagnostic tools or management strategies in infertile men. Many of these problems increase with age, leading to a growing population of men seeking help. To address this, there is a strong movement towards integrating male reproductive and sexual healthcare involving clinicians such as andrologists, urologists, endocrinologists and counselors. This book will emphasize this integrated approach to male reproductive and sexual health throughout the lifespan. Practical advice on how to perform both clinical and laboratory evaluations of infertile men is given, as well as a variety of methods for medically and surgically managing common issues. This text ties together the three major pillars of clinical andrology: clinical care, the andrology laboratory, and translational research.
Contents
Section I. An Introduction to Men's Health Care: 1. How has men's health changed over the past two decades?; 2. The business landscape of men's health; 3. Urologic men's health, the internet, and social media; Section II. The Biology of Male Reproduction and Infertility: 4. Current understanding of the physiology and histology of human spermatogenesis; 5. Male reproductive endocrinology; 6. Sperm chromatin packaging and the toroid linker model; 7. Ejaculation and sperm transport: physiology and clinical concerns; 8. Genetic aspects of male infertility; 9. The mechanistic and predictive utility of sperm epigenetics; 10. Aging and environmental interactions with the sperm epigenome; 11. The effects of aging on male fertility and the health of offspring; Section III. Clinical Evaluation and Treatment of Male Infertility: 12. Office evaluation of the infertile male; 13. Medical management of male fertility; 14. Surgical management of male infertility; 15. Varicocele repair in the era of ICSI; 16. Implementing genetic testing of male infertility in the clinic; 17. Andrological care of the patient with spinal cord injury; 18. Clinical fertility preservation decision making for prepubertal and postpubertal individuals with male gametes; 19. Mental health considerations in the infertile male and couple; Section IV. Laboratory Evaluation and Treatment of Male Infertility: 20. The modern semen analysis: theory and techniques of ejaculate examination; 21. The future of computer-assisted semen analysis in the evaluation of male infertility; 22. Reactive oxygen species and sperm DNA damage; 23. Clinical value of sperm DNA fragmentation tests; 24. The current use of sperm function assays; 25. Sperm selection in the laboratory; 26. Methods to select ejaculated, epididymal, and testicular spermatozoa for assisted conception; 27. Optimal sperm selection in the ICSI era; 28. Microfluidics for sperm sample preparation and sperm identification; 29. Practical concerns for patient semen banking; 30. The potential future applications of in vitro spermatogenesis in the clinical laboratory; 31. Spermatogonial stem cell culture and future of germline gene editing; Section V. Medical and Surgical Management of Issues of Male Health: 32. Hypogonadism in the male: evaluation and treatment; 33. Selective androgen receptor modulators (SARMs) in the treatment of hypogonadism and men's health; 34. Male fertility and testosterone therapy; 35. Sleep and men's health; 36. Molecular biology and physiology of erectile function and dysfunction; 37. Evaluation of the male with erectile dysfunction; 38. Lifestyle modifications for erectile dysfunction; 39. Medical and surgical management of erectile dysfunction; 40. Surgical management of Peyronie's disease; 41. Medical management of BPH; 42. Chronic orchialgia.
