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基本説明
Highlights the differences in pathologies of neurodegenerative diseases but also discusses the mechanistic similarities. Sections include: metal ions and prion diseases; metal ions and Alzheimer disease; manganese in brain functioning; metal involvement in Parkinson disease; and more.
Full Description
Bioinorganic chemistry has a cross disciplinary approach, applying the principles of chemistry to biological systems. Metallochemistry of Neurodegeneration: Biological, Chemical and Genetic Aspects discusses the rapidly developing area of metals in the nervous system and their role in neurodegenerative disease, such as Alzheimer's, Parkinson's and prion diseases. Written by leading experts in their fields, each chapter combines elements of genetics, biochemistry and biological inorganic chemistry in its discussion. The book highlights the differences in pathologies of neurodegenerative diseases but also discusses the mechanistic similarities. Sections include: metal ions and prion diseases; metal ions and Alzheimer disease; manganese in brain functioning; metal involvement in Parkinson disease; Cu-Zn superoxide dismutase and familial amyotrophic lateral sclerosis. This book will appeal to both chemists and biologists at the post graduate and research level.
Contents
Introduction
Blood-Brain Barrier and Roots of Entry of Metal Ions into the Brain. Metal Ion Transport and Distribution in the Brain
Metal Ion-Induced Redox Reactions, Oxidative Stress and Possible Impact on Neurodegeneration
Copper Metabolism in the Brain
Lithium, A Neuroprotective Element
Neurotoxicity of Aluminium
Manganese in the Brain Functioning
Alzheimer's Disease: Which Metal Now?
Prion Diseases and Redox Active Metals
Are Metals Involved in Cu-Zn Superoxide Dismutase Related Familial Amyotrophic Lateral Sclerosis
Parkinson's Disease: Any Role for Metals
Chelating Agents in Metal Neurotoxicity
Metal Complexes in the Brain Imaging and Diagnosis
