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Full Description
Macrocyclic lactones are chemical compounds that represent the main treatment for parasitic diseases of animals, not only for helminth infections, but also a number of major ectoparasitic infestations.There has been no comprehensive book on this subject for more than a decade and this book fills this gap and provides detailed coverage of the basic science of these drugs and their mode of action, as well as their clinical use in farm and companion animals and in humans.
Table of Contents
Contributors ix
Preface xiii
Chemistry, Pharmacology and Safety of the 1 (96)
Macrocyclic Lactones
Ivermectin, Abamectin and Eprinomectin 1 (29)
W. Shoop
M. Soll
Doramectin and Selamectin 30 (21)
G.A. Conder
W.J. Baker
Milbemycin Oxime 51 (24)
M. Jung
A. Saito
G. Buescher
M. Maurer
J.-F. Graf
Moxidectin 75 (22)
D.W. Rock
R.L. DeLay
M.J. Gliddon
Pharmacokinetics of the Macrocyclic 97 (28)
Lactones: Conventional Wisdom and New
Paradigms
D.R. Hennessy
M.R. Alvinerie
Mode of Action of the Macrocyclic Lactones 125 (16)
R.J. Martin
A.P. Robertson
A.J. Wolstenholme
Ecological Impact of Macrocyclic Lactones 141 (22)
on Dung Fauna
J.W. Steel
K.G. Wardhaugh
Resistance Against Macrocyclic Lactones 163 (20)
R.K. Prichard
The Use of Macrocyclic Lactones to Control 183 (120)
Parasites of Cattle
General Efficacy of the Macrocyclic 185 (38)
Lactones to Control Parasites of Cattle
J. Vercruysse
R. Rew
Use of Macrocyclic Lactones to Control 223 (25)
Cattle Parasites in Europe
J. Vercruysse
R. Rew
Use of Macrocyclic Lactones to Control 248 (14)
Cattle Parasites in the USA and Canada
R. Rew
J. Vercruysse
Use of Macrocyclic Lactones to Control 262 (26)
Cattle Parasites in South America
C. Eddi
A. Nari
J. Caracostantogolo
Use of Macrocyclic Lactones to Control 288 (15)
Cattle Parasites in Australia and New
Zealand
P.A. Holdsworth
The Use of Macrocyclic Lactones to Control 303 (20)
Parasites of Sheep and Goats
R.L. Coop
I. Barger
F. Jackson
The Use of Macrocyclic Lactones to Control 323 (16)
Parasites of Horses
C.M. Monahan
T.R. Klei
The Use of Macrocyclic Lactones to Control 339 (14)
Parasites of Pigs
J. Arends
J. Vercruysse
The Use of Macrocyclic Lactones in the 353 (18)
Control and Prevention of Heartworm and
Other Parasites in Dogs and Cats
J. Guerrero
J.W. McCall
C. Genchi
The Use of Macrocyclic Lactones to Control 371 (24)
Parasites of Domesticated Wild Ruminants
S.E. Marley
G.A. Conder
The Use of Macrocyclic Lactones to Control 395 (10)
Parasites of Exotic Pets
S.E. Little
C.B. Greenacre
R.M. Kaplan
The Use of Macrocyclic Lactones to Control 405 (8)
Parasites of Humans
K.R. Brown
Macrocyclic Lactones as Antiparasitic 413 (12)
Agents in the Future
T.G. Geary
Index 425