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Full Description
Recent understanding of the involvement of carbohydrate molecules and conjugates in many vital biological processes and, consequently, the appreciation of their tremendous therapeutic potential has stimulated the development of new methods for the synthesis of this class of compounds. The main efforts in the field of synthetic carbohydrate chemistry have been focused on the development of new glycosylation methodologies and convergent strategies for oligosaccharide
synthesis, in which the number of synthetic and purification steps is reduced. As a result, many efficient approaches have been developed both on the solid phase and in solution. This book brings together leading specialists working in the emerging areas of chemistry and biology on specific topics in
the area of carbohydrates. As a result, the book will be of great interest to scientists solving carbohydrate puzzles in many diverse areas of research.
Contents
1. Synthesis of modified monosaccharides as biological probes and therapeutic agents ; 1.1 Synthesis of 9-Substituted Sialic Acids As Probes for CD22-Ligand Interactions on B cells ; 1.2 Uncommon Sugars and Their Conjugates to Natural Products ; 1.3 Plant Cell Wall Glycans: Chemical Synthesis of the Branched Sugar Aceric Acid ; 1.4 Iodoamidation of Glycals: A Facile Preparation of 2-Deoxy-N-glycosylamides ; 2. New methods for stereoselective O-glycosylation ; 2.1 Stereocontrolled Glycosylation: Recent Advances: ?-D-Rhamnosides and ?-D-Mannans ; 2.2 Stereoselective Glycosylations Using Chiral Auxiliaries ; 2.3 Protecting Groups in Carbohydrate Chemistry Profoundly Influence All Selectivities in Glycosyl Couplings ; 2.4 Synthesis of N-5-Derivatives of Neuraminic Acid and their Application as Sialosyl Donors ; 3. New strategies for convergent oligosaccharide synthesis ; 3.1 2'-Carboxybenzylglycosides: A Novel Type of Glycosyl Donors and Their Application to Oligosaccharide Synthesis ; 3.2 Oligosaccharide Synthesis with Glycosyl Phosphates ; 3.3 Glycosyl thioimidates as versatile glycosyl donors for stereoselective O-glycosylation and convergent oligosaccharide synthesis ; 3.4 Sequential glycosylation strategies; a focus on thioglycosides as donors and acceptors ; 3.5 New Aspects of Glycoside Bond Formation - Solid Phase Oligosaccharide Synthesis ; 4. Chemical and enzymatic synthesis of therapeutically significant complex glycostructures ; 4.1 Synthesis of carbohydrate antigens related to Shigella dysenteriae type 1 and of their protein conjugates ; 4.2 Enzymatic Synthesis of Glycosaminoglycans: Improving on Nature ; 4.3 The chemical synthesis of glycosylphosphatidylinositol anchors from Trypanosoma cruzi trypomastigote mucins: exploration of ester and acetal type permanent protecting groups ; 4.4 Glycodiversification for the Synthesis of Neomycin and Kanamycin Class Aminoglycoside Antibiotics ; CONVERGENT N-GLYCOPEPTIDE SYNTHESIS ; 5. Special topics of modern glycochemistry ; 5.1 Targeting Galectin-1 with Self-Assembled Multivalent Pseudopolyrotaxanes ; 5.2 De Novo Synthesis of Biofunctional Carbohydrate-Encapsulated Quantum Dots
