Full Description
Enormous advances in our knowledge of genetic contributions to aging and disease, and in our understanding of the potential for manipulation of the aging process, have taken place during the past 20 years. This is the first volume in decades to consolidate this research in one place. It provides a broad and current overview of the most promising advances in genetic research on aging, current understanding of genetic contributions to the basic processes of aging, and age-related disease. The Review focuses on the aging process from lower organisms to man, and is organized in ascending order of biological complexity starting with stem cells and progressing through worms, flies, mice, and humans. Where relevant, the Review also includes information about yeasts and non-human primates.
The research presented in the Review uses a species-comparative approach that makes finding cross species similarities (gene conservation) and differences (gene differentiation) apparent. This approach reflects the way in which the field is organized, making it highly useful for investigators who want quick access and a concise summary of a particular topic.
Key Features:
Provides state-of-the-art information about promising advances in genetic research on aging
Comprises the first comprehensive volume regarding genetic research about aging in decades
Authored by leading scholars in the field
Disseminates enormous advances in our understanding of the aging process
Contents
Preface
1. Longevity pathways in mammalian stem cells
Anne Brunet, Salah Mahmoudi, Elena Mancini, Victoria A. Rafalski, and Ashley E. Webb
2. Essential Genes and Lifespan
Sean P. Curran
3. Oxygen and Aging
Jason N. Pitt, Scott F. Leiser, and M. Kaeberlein
4. Aging, Disease and Longevity in Mice
David B. Lombard and Richard A. Miller
5. Primate Models for Human Brain Aging and Neurological Diseases
Caleb Finch and Steve Austad
6. Genes for Exceptional Longevity
Nir Barzilai and Gil Atzmon
7. Etiology of Individual Differences in Human Health and Longevity
Deborah Finkel, Lotte Gerritsen, Chandra A. Reynolds, Anna K. Dahl, and Nancy L. Pedersen
8 Exploiting causal complexity in aging
Gerald E. McClearn, David J. Vandenbergh, J. Tobias Stout, and Roger J. McCarter
9. Networks in the Biology of Aging: Powerful tools for a complex process
Mark A. McCormick and Daniel E. L. Promislow
10. Nature, Nurture & Chance: Their Roles in Interspecific & Intraspecific Modulations of Aging
George M. Martin
