Full Description
Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs, Second Edition is a visually engaging reference detailing the essential basic and clinical science of all approved, effective, and life-prolonging drug therapies in oncology. Now with a greater emphasis on clinical context, application, and management in each chapter, this significantly revised edition provides both early-career and seasoned clinicians with a practical, bench-to-bedside approach and patient-oriented guide.
The book provides detailed coverage of the major advances in cancer pharmacology at the forefront of our standards of care for solid tumors and hematologic malignancies, in addition to the basic science that is directly necessary and applicable when at the patient's bedside. Everything from traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents is explored, in addition to a new chapter covering pharmacogenomics. Accompanied by elegant illustrations, each chapter details the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic and molecular properties of the various agents, and their mechanisms of action. The book covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Thoroughly updated to include new FDA-approved treatments and applications, and written by leading experts in cancer pharmacology, this second edition continues to be a "must have" for anyone involved in the basic, translational, or clinical aspects of oncology and hematology, including clinicians, pharmacists, nurses, and trainees.
Key Features:
Over 150 beautiful illustrations depict structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents
Contains more than 160 high-yield hematology and oncology board-style chapter review questions (more than double the previous edition) with descriptive rationales
Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work, and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other treatment modalities
Thoroughly updated and revised chapters cover new FDA drug approvals, disease-site indications, clinical applications and management of drug-to-drug interactions, and toxicities
Discusses challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments
Provides important pharmacotherapy context with clinical pearls in each chapter that help support a patient-oriented, bedside approach
Contents
List of Contributors
Preface
PART 1. BASIC PRINCIPLES OF CANCER PHARMACOLOGY AND CLINICAL DRUG DEVELOPMENT
Chapter 1. Drug Development in Oncology 101 by Edward A. Sausville, MD, PhD and Ashkan Emadi, MD, PhD
Chapter 2. Pharmacogenomics by Molly Graveno, PharmD, BCOP
Chapter 3. Critical Components of Clinical Trials Development: From Bench to Bedside and Back by S. Percy Ivy, MD, Richard F. Little, MD, and Joshua F. Zeidner, MD
Chapter 4. Drug Development and Regulatory Considerations by Vicky Hsu, PhD, Matthew D. Thompson, PhD, MPH, Donna Przepiorka, MD, PhD, and Olanrewaju O. Okusanya, Pharm.D., MS
PART 2. CLASSICAL CYTOTOXIC AGENTS
Chapter 5. Alkylating Agents and Drugs Perturbing DNA Structure by Ashkan Emadi, MD, PhD and Edward A. Sausville, MD, PhD
Chapter 6. Pyrimidine- and Purine-based Antimetabolites, Hydroxyurea, Asparaginases by Ashkan Emadi, MD, PhD and Judith E. Karp, MD
Chapter 7. Antifolate Antimetabolites by Justin Lawson, PharmD, BCOP
Chapter 8. Antimitotics by Edward A. Sausville, MD, PhD and Ashkan Emadi, MD, PhD
PART 3. EXPLOITING CELLULAR AND EXTRACELLULAR PATHWAYS
Chapter 9. Drugs Targeting DNA Repair, Cell Cycle and Apoptosis by Mira A. Kohorst, MD and Scott H. Kaufmann, MD, PhD
Chapter 10. Epigenetic Modulators by Sergiu Pasca, MD and Lukasz P. Gondek, MD, PhD
Chapter 11. Differentiating Agents and Microenvironment by Yuya Nagai, MD, PhD and Gabriel Ghiaur, MD, PhD
PART 4. ORGAN-TARGETED APPROACHES
Chapter 12. Targeted Therapeutics (Small Molecules) by Yuchen (Jake) Liu, MD and Ashkan Emadi, MD, PhD
Chapter 13. Hormonal Therapies Alone and in Combinations for Treatment of Breast Cancer by Amy M. Fulton, PhD and Katherine H. R. Tkaczuk, MD
Chapter 14. Androgen Receptor Axis Targeting in the Treatment of Prostate Cancer by Vincent C. O. Njar, PhD, and Arif Hussain, MD
Chapter 15. Multiple Myeloma as a Paradigm for Multi-Targeted Intervention by Kathryn Maples, PharmD, BCOP and Sagar Lonial, MD
PART 5. IMMUNE-TARGETED STRATEGIES
Chapter 16. Transplant-Related Agents: Focus on Graft vs. Host Disease Prevention and Treatment by Vedran Radojcic, MD
Chapter 17. Monoclonal Antibodies Including Immunoconjugates, Antibody-Drug Conjugates, Immunoconjugates, and Cytokine-Directed Agents by Alison Duffy, PharmD, BCOP and Ciera Bernhardi, PharmD, BCOP
Chapter 18. Immunotherapeutics: Immune Checkpoint Inhibitors, Vaccines, Bispecifics, and Engineered T Cells by Mark Yarchoan, MD and Elizabeth Jaffee, MD
Index
