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Full Description
Cellular Signal Processing is intended for use in signal transduction courses for undergraduate and graduate students. It offers a unifying view of cell signaling that is based on the concept of protein interactions acting as sophisticated data processing networks that govern intracellular and extracellular communication. The content is guided by three major principles that are central to signal transduction: the protein network, its energy supply, and its evolution. It includes coverage of all important aspects of cell signaling, ranging from prokaryotic signal transduction to neuronal signaling. It also highlights the clinical aspects of cell signaling in health and disease.
Contents
1. The "Brain of the Cell": Data Processing by Protein Networks
2. Supplying the Network with Energy: Basic Biochemistry of Signal Transduction
3. Evolution of Cellular Data Processing
4. Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases
5. Signal Transduction by Receptors with Seven Transmembrane Domains
6. Signal Transduction by Serine/Threonine Kinase-Coupled Receptors
7. Signal Transduction by Tyrosine Kinase- and Protein Phosphatase-Coupled Receptors: A Late Invention of Evolution
8. Gene Transcription: The Ultimate Target of Signal Transduction
9. Signals Controlling mRNA Translation
10. Signal Transduction by Small G-proteins: The Art of Molecular Targeting
11. Mitogen-activated Protein Kinase and Nuclear Factor ĸß Modules
12. Cancer and Regulation of Cell Division
13. Signal Transduction by Proteolysis and Programmed Cell Death
14. Signal Transduction by Ions
15. Sensory Signal Processing
16. Signaling at Synapses: Neurotransmitters and Their Receptors
17. Putting Together the Pieces: The Approach of Systems Biology
