基本説明
Written by experts at the forefront of current research and clinical practice, provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Previous ed.: 2004.
Full Description
Written by experts at the forefront of current research and clinical practice, Neonatal and Pediatric Pharmacology provides evidence-based guidelines for safe, effective, and rational drug therapy in newborns, children, and adolescents. Coverage includes specific recommendations for all major drug classes and diseases, a detailed section on drugs and the newborn, and chapters on specific treatment settings such as the pediatric intensive care unit and emergency room. Also included are chapters on adverse effects and interactions and state-of-the-art discussions on pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacogenomics, pharmacoproteomics, drug development, and clinical trials in infants and children. Appendices include a neonatal formulary and a pediatric formulary.The Fourth Edition includes updated information on drug interactions and regulatory issues. New chapters cover nutrient supplements and biotransformation of medications by the human placenta.
Contents
I1: Introduction and Historical Perspectives2: Clinical Pharmacokinetics in Infants and Children3: Drug Action and Therapy in the Infant and Child4: Drug Metabolism and Disposition in Infants and Children5: Pharmacogenetics, Pharmacogenomics, and Pharmacoproteomics6: Compliance with Pediatric Medication Regimens7: Clinical Trials Involving Children: History, Rationale, Regulatory Framework, and Technical Considerations8: Ethics of Drug Research in Pediatric Populations9: Therapeutic Drug Monitoring10: Drug FormulationsII: DRUGS AND THE NEWBORN11: Developmental Toxicology12: Biotransformation of Medications by Human Placenta13: Maternal Drug Intake and the Newborn14: Principles of Neonatal Pharmacology15: Perinatal Origins of Adult Defects in Drug Metabolism16: Renal Function and Excretion of Drugs in the Newborn17: The Excretion of Drugs and Chemicals in Human Milk18: Drugs for Hyperbilirubinemia19: Drugs and Lung Development20: Pharmacologic Treatment of Neonatal Apnea21: Drugs and Perinatal Brain Injury22: Antiretroviral Pharmacology in Pregnant Women and Newborns23: Therapeutic Applications in Pediatric Intensive Care24: Drug Therapy in the Pediatric Emergency Department25: Drug Therapy in the Adolescent26: Topical Medications27: Ophthalmologic Drugs in Infants and ChildrenIV: SPECIFIC DRUGS28: Sulfonamides29: Penicillins, Cephalosporins, and Other Beta-Lactams30: Aminoglycosides and Glycopeptides31: Fluoroquinolones32: Macrolides, Chloramphenicol, and Tetracyclines33: Anthelminthic Drugs in Children34: Antituberculosis Drugs35: Antifungal Agents36: Antiviral Drugs: Treatment of the Fetus and Newborn37: Anticonvulsants38: Psychopharmacology in Children and Adolescents39: Antihistamine Drugs40: Antiasthmatics41: Antipyretics42: Cardiovascular Drugs43: Diuretics44: Clinical Pharmacology of Antineoplastic Drugs45: Immunosuppressive and Immunomodulatory Drugs46: Analgesic Agents47: Local Anesthetics for Infants and Children48: Nonsteroidal Anti-inflammatory Drugs49: Antihypertensive Agents50: Gastrointestinal Drugs51: Glucocorticoids52: Insulin and Diabetes Mellitus53: Thyroid Hormones54: Growth Hormone55: Hematologic Agents56: Nutrient Supplements57: Childhood VaccinesV: ADVERSE DRUG EFFECTS AND INTERACTIONS58: Epidemiology of Adverse Drug Effects59: Mechanisms of Adverse Drug Reactions60: Medication Errors61: Pediatric Poisonings and Antidotes62: Use of Herbal Products in Children: Risks and Unproven Benefits63: Neonatal Abstinence Syndromes64: Drug Interactions in Newborns and ChildrenVI: APPENDIX65: Drug Formulary for the Newborn66: Pediatric Drug Formulary
