Full Description
This text thoroughly reviews the latest findings and concepts on the vascular biology of diabetes mellitus, the clinical vascular manifestations of diabetes, and the therapeutic options available for diabetic patients with vascular disease. The first section provides an in-depth understanding of fundamental principles and recent discoveries regarding diabetes mellitus and vascular biology. The second, clinically oriented section includes chapters on the economic implications of diabetes mellitus, risk profiling patients with diabetes, optimizing adjunctive therapies, and treatment strategies for diabetic patients with coronary and peripheral artery disease. Summaries of important clinical trials are included to provide an evidence-based approach to treatment.
Contents
Part I Vascular BiologyStructure and Function of the Vessel Wall, 3Mario B. Marrero and David M. SternAntioxidants, Oxidative Stress, and Inflammation in Diabetes, 19Sridevi Devaraj, Sonia Vega-Lopez, and Ishwarlal JialalRole of Protein Kinase C Isoforms in Diabetic Vascular Dysfunction, 37Zhiheng He, Ronald C.W. Ma, and George L. KingAldose Reductase and Vascular Stress, 55Ravichandran Ramasamy and Peter J OatesPeroxisome Proliferator-Activated Receptors and Diabetic Vasculature, 75Peter J. Little, Duncan J. Topliss, Sunder Mudalier, and Ronald E. LawReceptor-Dependent Vascular Stress in Diabetes, 93Ann Marie Schmidt, Barry I. Hudson, Shi-Fang Yan, and David M. SternGenetic Determinants of Late Diabetic Complications, 111Alessandro Doria, James H. Warram, and Andrzej S. KrolewskiDiabetic Retinopathy and Vascular Endothelial Growth Factor, 133Hans-Peter Hammes and Georg BreierPart II Clinical TopicsEpidemiology of Diabetes Mellitus and Cardiovascular Disease, 153Sunil V. Rao and Darren K. McGuireEconomic Implications of Diabetes Mellitus, 179John D. Nachtigal and Cathryn A. CarrollObesity, 199Mark W. Conard and Walker S. Carlos PostonDiabetes Treatment, 219William L. IsleyEndothelial Dysfunction, 239Joshua A. BeckmanPlatelet Dysfunction, 251Robert Kelly and Steven R. SteinhublDiabetes, Impaired Fibrinolysis, and Thrombosis, 269Peter J. Grant and Lucinda K.M. SummersRestenosis, 293David S. Lee and Marc S. PennThe Renin-Angiotensin System, Nephropathy, and Hypertension, 315Roberto Trevisan and Giancarlo VibertiLipoprotein Abnormalities, 337William L. Isley and William S. HarrisDiabetes Mellitus and Ischemic Heart Disease, 355Benjamin H. Trichon and Matthew T. RoeDiabetes and Coronary Revascularization, 379Deepak P. Vivekananthan and Deepak L. BhattDiabetes and Peripheral Artery Disease, 403Roberto A. CorpusAppendix A. Adjunctive Pharmacology of Diabetes: Chain of Evidence, 423Maureen E. Knell, Jared T. Lurk, and Jennifer M. RothAppendix B. Synopsis of Major Cardiovascular Trials Involving Diabetic Patients, 469Avinash KhannaSubject Index, 487
