The cellular events underlying rapid cellular damage in different organs are potentially of great medical importance, for example muscular dystrophy, liver damage and the preservation of kidneys for transplantation. Many hypotheses exist for the biochemical pathways involved in these damage processes. The roles of calcium and active oxygen metabolites are of particular interest. There is considerable literature on both these triggering agents and good evidence for their involvement in the genesis of damage, although little agreement on their precise roles. This volume records the proceedings of a meeting held by the Society for Experimental Biology that attempted to determine whether there are common mechanisms of cellular damage and to explore the ways in which calcium and oxygen radicals may interact to generate damage. The questions addressed, in particular, are whether there are any common biochemical pathways, and the specific and possibly interacting roles of calcium and active oxygen metabolites.
Table of Contents
1. Are there common biochemical pathways in
cell damage and cell death? C. J. Duncan
2. Free radicals in the pathogenesis of tissue
damage M. J. Jackson
3. Calcium and signal transduction in oxidative
cell damage P. Nicotera, G. E. N. Kass, S. K.
Duddy and S. Orrenius
4. Regulation of neutrophil oxidant production
S. W. Edwards
5. Reperfusion arrhythmias: role of oxidant
stress M. J. Shattock, H. Matsuura and D. J.
6. Biochemical pathways that lead to the
release of cytosolic proteins in the perfused
rat heart C. J. Duncan
7. Malignant hyperthermia: the roles of free
radicals and calcium? J. R. Arthur and G. G.
8. Free radicals, calcium and damage in
dystrophic and normal skeletal muscle M. J.
Jackson, A. McArdle and R. H. T. Edwards
9. Ultrastructural changes in mitochondria
during rapid damage triggered by calcium C. J.
Duncan and N. Shamsadeen
10. The importance of oxygen free radicals,
iron and calcium in renal ischaemia J. D.
Gower, L. A. Cotterill and C. J. Green
11. The Rubicon Hypothesis: a quantal framework
for understanding the molecular pathway of cell
activation and injury A. K. Campbell.