Full Description
First published in 1986, this volume reviews the immune system of domestic ruminants, with particular emphasis on mechanisms of immunity and resistance to infectious diseases. Topics of comparative interest in other species are also covered. The cellular components of the immune system are discussed first, including ontogeny, structural organization and how they interact during the generation of immune responses. This is followed by information on specific aspects of humoral and cell-mediated immune responses, and finally a section on the relevance of various types of immune responses in protection against a number of important infectious diseases of ruminants. The papers included were presented originally at an international conference held in Nairobi, Kenya in September 1983. They provide authoritative coverage of a wide range of topics in ruminant immunology. Together, they comprise a valuable reference text for those involved in all aspects of immunological research in ruminants.
Contents
List of authors; Preface; 1. Evolution and functions of the immune system A. J. S. Davies; Part I. Cellular Components of the Immune System: 2. Lymphocyte subpopulations in the mouse R. Scollay; 3. Definition of lymphocyte subpopulations in man P. C. L. Beverley; 4. Definition of lymphocyte populations in cattle using lectins C. Fossum; 5. Monoclonal antibodies to bovine leucocytes define heterogenicity of target cells for in vitro parasitosis by theileria parva P. A. Lalor, W. I. Morrison and S. J. Black; 6. Construction of a library of monoclonal antibodies for the analysis of the major histocompatibility gene complex and the immune system in ruminants W. C. Davis, L. E. Perryman and T. C. McGuire; Part II. The Major Histocompatibility Complex: 7. The human lymphocyte antigen system J. A. Sachs; 8. The bovine major histocompatibility complex R. L. Spooner; 9.Biochemical analysis of products of the bovine major histocompatibility complex D. Lévy, M. Hoang-Xuan and M. T. Zilber; 10. The role of the major histocompatibility complex in immune responses and susceptibility to disease R. V. Blanden; 11. The bovine major histocompatibility complex and disease resistance T. E. Adams and M. R. Brandon; Part III. Structural Organization and Ontogeny: 12. The lymphoid apparatus of the sheep and the recirculation of lymphocytes B. Morris N. C. Pedersen and W. Trevella; 13. Cellular constituents and structural organization of the bovine thymus and lymph node W. I. Morrison, P. A. Lalor, A. K. Christensen and P. Webster; 14. Ontogeny of immune responses in cattle B. I. Osburn; Part IV. Cellular Immune Responses: 15. Regualtory and effector cell interactions in immune responses R. N. Germain; 16. The analysis of the effects of lymphokines on cytotoxic T-cell responses M. A. Skinner, N. Christensen and J. Morbrook; 17. Bovine mixed leucocyte reactions and generation of cytotoxic cells B. M. Goddeeris, P. A. Lalor and W. I. Morrison; 18. Bovine alloreactive cytotoxic T cells A. J. Teale, W. I. Morrison, R. L. Spooner, B. M. Goddeeris, C. M. Groocock and D. A. Stagg; 19. Antibody-dependent cellular cytotoxicity and natural killer cell activity in cattle: mechanisms of recovery from infectious diseases M. P. Lawman, D. Gauntlett and F. Gallery; Part V. Humoral Immune Responses: 20. Structure and function of immunoglobulins: the symbiotic interplay between parasites and antibodies R. Hamers, W. van der Loo and P. De Baetselier; 21. Biological properties of bovine immunoglobulins and systemic antibody responses A. J. Musoke, F. R. Rurangirwa and V. M. Nantulya; 22. The physiology of secretory immunity J. G. Hall; 23. The mucosal immune system with particular reference to ruminant animals A. K. Lascelles, K. J. Beh, T. K. Mukkur and D. L. Watson; Part VI. Role of Immune Responses in Protection Against Infectious Diseases: 24. Effector mechanisms against viral infections L. D. Pearson and K. A. Knisley; 25. Immunogenicity of different physical forms of viral antigenic subunits B. Morein; 26. Mucosal mast cells, basophils, immediate hypersensitivity reactions and protection against gastrointestinal nematodes H. R. P. Miller; 27. Host responses which control Trypanosoma brucei parasites S. J. Black; 28. Studies on the protection of cattle against Babesia bovis infection D. F. Mahoney; 29. Protective immune responses in bovine theileriosis W. I. Morrison, D. L. Emery, A. J. Teale and B. M. Goddeeris.
