Cellular Basis of Morphogenesis Chairman: L. Wolpert 1989 The establishment of body pattern in developing embryos has been studied since early this century. Descriptive accounts have been superseded by systematic screening for mutants, identification of the genes involved and isolation of these genes; firstly in organisms such as Drosophila where genetic techniques are well established, more recently in mammals using transfection and insertional mutagenesis. This book focuses on the interface between genes and cells, covering genetic analysis, cloning studies, and the investigation of cell lineages and cellular interactions. The opening chapters describe how the body axes are already determined in the eggs of invertebrates and amphibia. In all species, as the egg cleaves, cells are assigned to specific lineages, which give rise to different tissues in the adult. The mechanisms underlying these processes in annelids, arthropods, amphibia and mice are discussed. After a cell has adopted a particular fate, its position in the final body plan is the result of cell sorting and, in some cases, cell migration. The final chapters cover the characterization of the molecules that mediate these activities. Related Ciba Foundation Symposia: No 138 Plasticity of the neuromuscular system Chairman: A. J. Buller 1988 ISBN 0 471 91902 0 No 145 Carbohydrate recognition in cellular function Chairman: E. Ruoslahti 1989 ISBN 0 471 92307 9 (in press)
Table of Contents
PARTIAL TABLE OF CONTENTS: Partial table of
The Cellular Interphase (A. Garcia-Bellido).
Localization of mRNA and Axis Formation
During Xenopus Embryogenesis (D. Melton, et
Morphogen Gradients and the Control of Body
Pattern in Insect Embryos (G. Struhl).
The Establishment of Regional Identity in the
Xenopus Blastula (J. Heasman, et al.).
Factors Specifying Cell Lineages in the Leech
(D. Weisblat & S. Astrow).
n Vivo Competition Identifies Positive
Cis-Regulatory Elements Required for
Lineage-Specific Gene Expression in the Sea
Urchin Embryo (R. Franks, et al.).
Cell Allocation and Lineage in the Early
Mouse Embryo (R. Gardner).
Induction and Organization of the Body Plan
in Xenopus Development (J. Cooke).
Structure and Function of the Bithorax
Complex Genes of Drosophila (A. Busturia, et
Cadherin-Mediated Specific Cell Adhesion and
Animal Morphogenesis (M. Takeichi, et al.).
Polarity and Patterning in the Neural Tube:
The Origin and Function of the Floor Plate
(T. Jessell, et al.).
Cellular Communication in the Developing
Drosophila Eye (A. Tomlinson).
Index of Contributors.