Full Description
In the early 1980s, adverse reactions reports on phenylpropanolamine, available in over-the-counter cough/cold remedies and weight control remedies for the past 65 years, began to appear with increasing frequency. This text was developed from a comprehensive search of the published literature worldwide on the benefits, risks and controversy surrounding the medication. Each chapter addresses controversial topics such as the relationship of phenylpropanolamine to khat and Ma Huang, national differences in nomenclature conventions, the questionable chemical identity and analytical purity of certain products, the relationships among phenylpropanolamine, ephedrine and amphetamine, and more. Also examined are drug interactions, cardiovascular and central nervous system effects.
Contents
History: Early Studies of Phenylpropanolamine: Synthesis and Patenting; Early Basic Pharmacology Studies; Therapeutic Uses; Street Drug Abuse: Amphetamine Look-alikes, Pseudospeed and Counterfeit Controlled Substances; Chemistry: Stereochemistry of Phenylpropanolamine; Synthesis of Phenylpropanolamine; Pharmaceutical Preparations Containing Phenylpropanolamine; Chemical Analysis of Phenylpropanolamine; Basic Pharmacology: Pharmacokinetics; Pharmacodynamics; Safety: Toxicology; Adverse Effects; Overdose Cases; Adverse Drug Interactions; Clinical Pharmacology: Efficacy of Phenylpropanolamine as a Decongestant in Cough/Cold Preparations; Efficacy of Phenylpropanolamine as an Anorectic Drug in the Treatment of Obesity; Efficacy of Phenylpropanolamine in Treatment of Urinary Incontinence; Use of Phenylpropanolamine for Correction of Retrograde Ejaculation; Clinical Safety Studies.
