Full Description
Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells.
Coverae includes:
the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems
the cellular physiology of the different kinds of glial cells
the mechanisms of intra- and inter-cellular signalling in glial networks
the mechanisms of glial-neuronal communications
the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system
the cellular and molecular mechanisms of metabolic neuronal-glial interactions
the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's
Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it.
An up-to-date and fully referenced text on the most numerous cells in the human brain
Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system
Describes the role og glial cells in neuropathology
Focus boxes highlight key points and summarise important facts
Companion website with downloadable figures and slides
Contents
Preface xvii
About the Authors xxi
Abbreviations xxv
About the Companion Website xxxii
1 History of Neuroscience and the Dawn of Research in Neuroglia 1
1.1 The miraculous human brain: localising the brain functions 1
1.2 Cellular organisation of the brain 10
1.3 Mechanisms of communications in neural networks 14
1.4 The concept of neuroglia 27
1.5 Beginning of the modern era 47
1.6 Concluding remarks 49
References 49
2 General Overview of Signalling in the Nervous System 59
2.1 Intercellular signalling: wiring and volume modes of transmission 59
2.2 Cellular signalling: receptors 62
2.3 Intracellular signalling: second messengers 67
2.4 Calcium signalling 67
2.5 Concluding remarks 72
3 Neuroglia: Definition, Classification, Evolution, Numbers, Development 73
3.1 Definition of neuroglia as homeostatic cells of the nervous system 74
3.2 Classification 75
3.3 Evolution of neuroglia 76
3.4 Numbers: how many glial cells are in the brain? 93
3.5 Embryogenesis and development of neuroglia in mammals 96
3.6 Concluding remarks 99
References 100
4 Astroglia 105
4.1 Definition and heterogeneity 107
4.2 Morphology of the main types of astroglia 113
4.3 How to identify astrocytes in the nervous tissue 119
4.4 Astroglial syncytial networks 120
4.5 Physiology of astroglia 125
4.6 Functions of astroglia 175
4.7 Concluding remarks 231
References 231
5 Oligodendrocytes 245
5.1 Oligodendrocyte anatomy 247
5.2 Myelin structure and function 252
5.3 Physiology of oligodendrocytes 266
5.4 Oligodendrocyte development 283
5.5 Concluding remarks 299
References 299
6 NG2-glial Cells 321
6.1 Definition of NG2-glia 321
6.2 Structure of NG2-glia 324
6.3 Physiology of NG2-glia 327
6.4 Proliferation of NG2-glia and generation of oligodendrocytes 332
6.5 Relationship between NG2-glia and CNS pericytes 333
6.6 Evolution of NG2-glia 336
6.7 Concluding remarks 337
References 337
7 Microglia 343
7.1 Definition of microglia 344
7.2 Microglial origin and development 345
7.3 Morphology of microglia 345
7.4 General physiology of microglia 351
7.5 Microglial migration and motility 372
7.6 Physiological functions of microglia: role in synaptic transmission and plasticity 373
7.7 Microglia in ageing 375
7.8 Concluding remarks 375
References 376
8 Peripheral Glial Cells 381
8.1 Peripheral nervous system 382
8.2 Schwann cells 390
8.3 Satellite glial cells 407
8.4 Enteric glia 412
8.5 Olfactory ensheathing cells (OECs) 418
8.6 Concluding remarks 422
References 423
9 General Pathophysiology of Neuroglia 431
9.1 Neurological disorders as gliopathologies 431
9.2 Reactive astrogliosis 433
9.3 Wallerian degeneration 439
9.4 Excitotoxic vulnerability of oligodendrocytes: the death of white matter 442
9.5 Activation of microglia 444
9.6 Concluding remarks 449
References 450
10 Neuroglia in Neurological Diseases 453
10.1 Introduction 454
10.2 Genetic astrogliopathology: Alexander disease 456
10.3 Stroke and ischaemia 458
10.4 Migraine and spreading depression 467
10.5 CNS oedema 469
10.6 Metabolic disorders 471
10.7 Toxic encephalopathies 473
10.8 Neurodegenerative diseases 474
10.9 Leukodystrophies 487
10.10 Epilepsy 488
10.11 Psychiatric diseases 490
10.12 Autistic disorders 491
10.13 Neuropathic pain 492
10.14 Demyelinating diseases 494
10.15 Infectious diseases 496
10.16 Peripheral neuropathies 499
10.17 Gliomas 501
10.18 Concluding remarks 504
References 504
Author Index 513
Subject Index 517
