基本説明
Concisely covers basic science and offers latest clinical and therapeutic applications, including cutting-edge topics such as gene therapy and active specific immunotherapy of human tumours by viral vectors.
Full Description
Clinical oncologists and researchers now have a comprehensive single source of current information on cancer viruses obtained from bench and bedside. This important refernce allows further development of translational approaches for the effective treatment of patients with virus-associated malignancies. The book contains 25 chapters covering basic and clinical aspects of viruses, including HPV, HBV, HCV, polyomaviruses, Kaposi's associated viruses, retroviruses (including HIV-1 associated malignancies), and EBV. Several chapters are devoted to basic science of oncogenic viruses for the study of their pathogenesis, drug development, and employment of viral vectors for vaccine and gene therapy. Clinical materials are embedded within chapters, and there are also complementary, clinically based chapters describing natural courses and treatments.
Contents
Foreword vii
Preface xi
Contributors xiii
1 HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS 1
Rachel A. Katzenellenbogen and Denise A. Galloway
2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS-INDUCED HUMAN CANCERS 23
Amy Baldwin and Karl Münger
3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57
Miranda Thomas, David Pim, and Lawrence Banks
4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN-LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89
Krzysztof Reiss, Kamel Khalili, and Luis Del Valle
5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113
C. Richard Boland, Luigi Ricciardiello, and Ajay Goel
6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129
Michael J. Imperiale and Dweepanita Das
7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149
Abhilasha V. Rathi and James M. Pipas
8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165
Janet S. Butel
9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191
Natalya Baranova and Michele Carbone
10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B-ASSOCIATED VIRAL CANCER 211
Timothy M. Block and Anand S. Mehta
11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225
Mei-Hwei Chang and Ding-Shinn Chen
12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243
Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun
13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS-INDUCED CELLULAR TRANSFORMATION 267
Donna Sir and Jing-Hsiung James Ou
14 CLINICAL ASPECTS OF HTLV-1-ASSOCIATED CANCER 279
Masao Matsuoka
15 ONCOGENIC POTENTIAL OF THE HTLV-1 TAX PROTEIN 295
Susan J. Marriott
16 HIV-1-ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317
Melissa Agsalda and Bruce Shiramizu
17 HIV-RELATED LYMPHOMA 337
Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini
18 BIOLOGY AND EPIDEMIOLOGY OF HHV-8 351
Veenu Minhas and Charles Wood
19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI'S SARCOMA 377
Gary S. Hayward, Donald J. Alcendor, and Ravit Arav-Boger
20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409
Joseph S. Pagano
21 EPSTEIN-BARR VIRUS AS A PATHOGEN 425
Wasim A. Dar and Bill Sugden
Index 453
