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Full Description
Applications of Time-of-Flight and Orbitrap Mass Spectrometry in Environmental, Food, Doping, and Forensic Analysis deals with the use of high-resolution mass spectrometry (MS) in the analysis of small organic molecules. Over the past few years, time-of-flight (ToF) and Orbitrap MS have both experienced tremendous growth in a great number of analytical sectors and are now well established in many laboratories where high requirements are placed on analytical performance.
This book gives a head-to-head comparison of these two technologies that compete directly with each other. As users with hands-on experience in both techniques, the authors provide a balanced description of the strengths and weaknesses of both techniques. In the vast majority of cases, ToF-MS and Orbitrap-MS have been used for qualitative purposes, mainly identification of discrete molecular entities such as drug metabolites or transformation products of environmental contaminants.
This paradigm is now changing as quantitative capabilities are increasingly being explored, as are non-target approaches for unbiased broad-scope screening. In view of the continuous innovation of high-resolution MS instrument manufacturers in designing and developing more powerful machines, technological advances in both hardware and software are considerable, with many novel applications.
This book summarizes and analyzes these trends. The compilation of selected examples from diverse analytical fields will allow the readers to discover not only the potential of high-resolution MS in their sector, but also shows advances in other fields that rely on hi-res MS.
Contents
Instrumentation
Orbitrap Mass Spectrometry: Evolution and Applicability
Claudia P.B. Martins, Maciej Bromirski, Mari C. Prieto Conaway and Alexander A. Makarov
Advances in Time of Flight Mass Spectrometry
John C. Fjeldsted
Ambient Ionization-High Resolution Mass Spectrometry: Environmental, Food, Forensic and Doping Analysis.
Raquel Seró, Óscar Núñez and Encarnación Moyano
Target Analysis, Identification, and Suspect Screening
High Resolution Mass Spectrometry in Doping Control
Georgina Balcells, Oscar J. Pozo and Rosa Ventura
Application of LC-Time of Flight and Orbitrap-MS/MS for Pesticide Residues in Fruits and Vegetables
Łukasz Rajski, María del Mar Gómez Ramos and Amadeo R. Fernández-Alba
Identification of Sildenafil Designer Analogues Found in Dietary Supplements
Xiaowei Ge, Chee-Leong Kee, Yun Zeng and Min-Yong Low
High-Resolution Mass Spectrometry in Metabolite Identification
Mayurbhai Kathadbhai Ladumor, Shristy Tiwari, Amol Patil, Krishna Bhavsar, Shalu Jhajra, Bhagwat Prasad and Saranjit Singh
LC-TOF-MS for the Identification of Environmental Metabolites and Degradation Products
Imma Ferrer, Jeffrey H. Writer, Olya S. Keen, Yaal Lester, Juan A. Padilla-Sánchez, Carolina Fernández-Ramos and E. Michael Thurman
Application of Orbitrap Mass Spectrometry for the Identification of Transformation Products of Trace Organic Contaminants Formed in the Environment
Carsten Prasse and Thomas A. Ternes
High Resolution-Mass Spectrometry Identification of Micropollutants Transformation Products Produced During Water Disinfection with Chlorine and Related Chemicals
Iria González-Mariño, Inmaculada Carpinteiro, Rosario Rodil, Isaac Rodríguez and José Benito Quintana
Discovery of New Emerging DBPs by High Resolution Mass Spectrometry
Susan D. Richardson and Cristina Postigo
Suspect Screening of Pharmaceuticals and Related Bioactive Compounds, Their Metabolites and Their Transformation Products in the Aquatic Environment, Biota and Humans Using LC-HR-MS Techniques
Jaume Aceña, Nubia Heuett, Piero Gardinali and Sandra Pérez
Non-Target Analysis
Non-Target Analysis of Environmental Samples Based on Liquid Chromatography Coupled to High Resolution Mass Spectrometry (LC-HRMS)
Pablo Gago-Ferrero, Emma L. Schymanski, Juliane Hollender and Nikolaos S. Thomaidis
Non-Targeted Analysis of Persistent Organic Pollutants by Mass Spectrometry and GCxGC
Xavier Ortiz Almirall, Miren Pena Abaurrea, Karl J. Jobst and Eric J. Reiner
High Resolution Mass Spectrometry in the Effect-Directed Analysis of Water Resources
Martin Krauss
Conclusions
Conclusions and Future Directions Peter Eichhorn and Sandra Pérez
