Progress in Medicinal Chemistry (Progress in Medicinal Chemistry)

King, F.D. (EDT)/ Lawton, G. (EDT)

Elsevier Science Ltd（2006/04発売）

• 製本 Hardcover:ハードカバー版／ページ数 404 p.
• 言語 ENG
• 商品コード 9780444517371
• DDC分類 615.19

基本説明

Describes recent progress towards drugs acting at a range of 'druggable' targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors.

Full Description

The perceived lack of drug discovery productivity in recent times has led to much debate in the pharmaceutical/biotechnology industry as escalating R&D costs are not being matched by increased output. Few observers doubt that selecting the right targets, ie those which are critical to disease pathology and are 'druggable', is the best starting point for improved productivity.

The seven chapters of this volume describe recent progress towards drugs acting at a range of 'druggable' targets. One chapter addresses kinases, one covers an ion channel, two proteases are featured and three of the chapters cover G-protein coupled receptors, which has historically perhaps been the most fruitful area for medicinal chemists.

Contents

1. Finding Protein Kinase Hits Using Structural Information
2. Blunting the Swiss Army Knife
3. Peptide Deformylase Inhibitors
4. Clinically Useful Vanilloid Receptor TRPV1 Antagonists
5. Recent Medicinal Chemistry of the Histamine H3 Receptor
6. Recent Progress in Cannabinoid research
7. Oxytocin Antagonists as Potential Therapeutic Agents