Biosensors : Kinetics of Binding and Dissociation Using Fractals

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Biosensors : Kinetics of Binding and Dissociation Using Fractals

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  • 製本 Hardcover:ハードカバー版/ページ数 450 p.
  • 言語 ENG
  • 商品コード 9780444515124
  • DDC分類 610.28

基本説明

Timely sequel to popular title, Engineering Biosensors: Kinetics and Design Applications.

Full Description


This title brings to the attention of researchers in the industry, and in academia, the application of fractals to help in modeling the analyte/receptor binding and dissociation kinetics on biosensor surfaces.The work builds on that done in Engineering Biosensors: Kinetics and Design Applications, published by Academic Press in 2002. In particular, more examples are provided of where biosensors may be effectively used. This sequel is extremely timely, given the anticipation that the applications and reliance on biosensors will increase due to the advances in miniaturization, (wireless) communications, and the development of new materials (especially biological and chemical). Other applications of biosensors on the increase can be found in: the protection of civilian structures and infrastructures; protection from possible biological and chemical threats; health care; energy; food safety; and the environment to name a few.

Table of Contents

Foreword                                           vii
Preface ix
1. Introduction 1 (16)
1.1 Definition and Expanding Needs of 1 (3)
Biosensors
1.2 Advantages and Disadvantages of 4 (4)
Biosensors
1.3 Newer Applications: Present and Future 8 (2)
1.4 Biosensor Economics 10 (3)
1.5 Overview 13 (1)
References 14 (3)
2. Effect of Reynolds Number on Fractal 17 (14)
Binding Kinetics on a surface-Based Biosensor
2.1 Introduction 17 (1)
2.2 Theory 18 (2)
Single-Fractal Analysis 18 (2)
2.2.1 Binding Rate Coefficient 18 (2)
Dual-Fractal Analysis 20 (14)
2.2.2 Binding Rate Coefficient 20 (1)
2.3 Results 20 (5)
2.3.1 Straight Channel Biosensor 21 (2)
2.3.2 Serpentine Channel Biosensor 23 (2)
2.4 Boundary Layer Analysis and Sherwood 25 (2)
Number
2.5 Conclusions 27 (1)
References 28 (3)
3. DNA Fractal Binding and Dissociation 31 (26)
Kinetics
3.1 Introduction 31 (3)
3.2 Theory 34 (2)
Single-Fractal Analysis 34 (1)
3.2.1 Binding Rate Coefficient 34 (1)
3.2.2 Dissociation Rate Coefficient 35 (1)
Dual-Fractal Analysis 35 (24)
3.2.3 Binding Rate Coefficient 35 (1)
3.2.4 Dissociation Rate Coefficient 35 (1)
3.3 Results 36 (16)
3.4 Conclusions 52 (2)
References 54 (3)
4. Fractal Analysis of Binding and 57 (28)
Dissociation Interactions of Estrogen
Receptors to Ligands on Biosensor surfaces
4.1 Introduction 57 (2)
4.2 Theory 59 (2)
Single-Fractal Analysis 60 (1)
4.2.1 Binding Rate Coefficient 60 (1)
4.2.2 Dissociation Rate Coefficient 60 (1)
Dual-Fractal Analysis 61 (27)
4.2.3 Binding Rate Coefficient 61 (1)
4.2.4 Dissociation Rate Coefficient 61 (1)
4.3 Results 61 (21)
4.4 Conclusions 82 (2)
References 84 (1)
5. A Fractal Analysis of Analyte-Estrogen 85 (22)
Receptor Binding and Dissociation Kinetics
Using Biosensors: Environmental Effects
5.1 Introduction 85 (3)
5.2 Theory 88 (2)
Single-Fractal Analysis 89 (1)
5.2.1 Binding Rate Coefficient 89 (1)
5.2.2 Dissociation Rate Coefficient 89 (1)
Dual-Fractal Analysis 89 (21)
5.2.3 Binding Rate Coefficient 89 (1)
5.2.4 Dissociation Rate Coefficient 90 (1)
5.3 Results 90 (13)
5.4 Conclusions 103(2)
References 105(2)
6. A Fractal Analysis of Analyte-Estrogen 107(26)
Receptor Binding and Dissociation Kinetics
Using Biosensors: Biomedical Effects
6.1 Introduction 107(3)
6.2 Theory 110(3)
Single-Fractal Analysis 110(2)
6.2.1 Binding Rate Coefficient 110(1)
6.2.2 Dissociation Rate Coefficient 111(1)
Dual-Fractal Analysis 112(24)
6.2.3 Binding Rate Coefficient 112(1)
6.2.4 Dissociation Rate Coefficient 113(1)
6.3 Results 113(17)
6.4 Conclusions 130(1)
References 131(2)
7. Fractal Analysis of Binding Interactions 133(26)
of Nuclear Estrogen Receptors Occurring on
Biosensor surfaces
7.1 Introduction 133(3)
7.2 Theory 136(1)
Single-Fractal Analysis 136(1)
7.2.1 Binding Rate Coefficient 136(1)
7.2.2 Dissociation Rate Coefficient 136(1)
Dual-Fractal Analysis 137(25)
7.2.3 Binding Rate Coefficient 137(1)
7.2.4 Dissociation Rate Coefficient 137(1)
7.3 Results 137(18)
7.4 Conclusions 155(2)
References 157(2)
8. A Kinetic Study of Analyte-Receptor 159(24)
Binding and Dissociation for Biosensor
Applications: A Fractal Analysis for Cholera
Toxin and Peptide-Protein Interactions
8.1 Introduction 159(3)
8.2 Theory 162(5)
Variable Binding Rate Coefficient 163(1)
Single-Fractal Analysis 164(2)
8.2.1 Binding Rate Coefficient 164(1)
8.2.2 Dissociation Rate Coefficient 165(1)
Dual-Fractal Analysis 166(19)
8.2.3 Binding Rate Coefficient 166(1)
8.2.4 Dissociation Rate Coefficient 166(1)
8.3 Results 167(12)
8.4 Conclusions 179(1)
References 180(3)
9. The Temporal Nature of the Binding and 183(22)
Dissociation Rate Coefficients and the
Affinity Values for Biosensor Kinetics
9.1 Introduction 183(2)
9.2 Theory 185(4)
Single-Fractal Analysis 186(2)
9.2.1 Binding Rate Coefficient 186(1)
9.2.2 Dissociation Rate Coefficient 187(1)
Dual-Fractal Analysis 188(20)
9.2.3 Binding Rate Coefficient 188(1)
9.2.4 Dissociation Rate Coefficient 188(1)
9.3 Results 189(11)
9.4 Conclusions 200(2)
References 202(3)
10. Fractal Analysis of Analyte-Receptor 205(28)
Binding and Dissociation, and Dissociation
Alone for Biosensor Applications
10.1 Introduction 205(3)
10.2 Theory 208(4)
Variable Binding Rate Coefficient 208(1)
Single-Fractal Analysis 209(2)
10.2.1 Binding Rate Coefficient 209(1)
10.2.2 Dissociation Rate Coefficient 210(1)
Dual-Fractal Analysis 211(26)
10.2.3 Binding Rate Coefficient 211(1)
10.2.4 Dissociation Rate Coefficient 211(1)
10.3 Results 212(15)
10.4 Conclusions 227(1)
References 228(5)
11. Fractal Analysis of Cellular 233(32)
Analyte-Receptor Binding and Dissociation on
Biosensors
11.1 Introduction 233(4)
11.2 Theory 237(4)
Variable Binding Rate Coefficient 237(1)
Single-Fractal Analysis 238(2)
11.2.1 Binding Rate Coefficient 238(1)
11.2.2 Dissociation Rate Coefficient 239(1)
Dual-Fractal Analysis 240(27)
11.2.3 Binding Rate Coefficient 240(1)
11.2.4 Dissociation Rate Coefficient 240(1)
11.3 Results 241(18)
11.4 Conclusions 259(1)
References 260(5)
12. Analyte-Receptor Binding Kinetics on 265(30)
Microarrays: A Fractal Analysis
12.1 Introduction 265(2)
12.2 Theory 267(1)
Single-Fractal Analysis 267(1)
12.2.1 Binding Rate Coefficient 267(1)
Dual-Fractal Analysis 268(28)
12.2.2 Binding Rate Coefficient 268(1)
12.3 Results 268(22)
12.4 Conclusions 290(2)
References 292(3)
13. Analyte-Receptor Binding on SPR Biosensors: 295(22)
A Fractal Analysis of Cre-loxP Interactions and
the Influence of Cl, O, and S on Drug-Liposome
interactions
13.1 Introduction 295(1)
13.2 Theory 296(4)
Single-Fractal Analysis 297(2)
13.2.1 Binding Rate Coefficient 297(1)
13.2.2 Dissociation Rate Coefficient 298(1)
Dual-Fractal Analysis 299(19)
13.2.3 Binding Rate Coefficient 299(1)
13.2.4 Dissociation Rate Coefficient 299(1)
13.3 Results 300(13)
13.4 Conclusions 313(1)
References 314(3)
14. Binding and Dissociation Kinetic Using 317(22)
Fractals: An Analysis of Electrostatic Effects
and Randomly Coupled and Oriented Coupled
Receptors on Biosensor Surfaces
14.1 Introduction 317(1)
14.2 Theory 318(2)
Single-Fractal Analysis 318(1)
14.2.1 Binding Rate Coefficient 318(1)
14.2.2 Dissociation Rate Coefficient 319(1)
Dual-Fractal Analysis 319(22)
14.2.3 Binding Rate Coefficient 319(1)
14.2.4 Dissociation Rate Coel ient 320(1)
14.3 Results 320(17)
14.4 Conclusions 337(1)
References 338(1)
15. A Study of Analyte-Receptor Binding and 339(22)
Dissociation on Biosensor Surfaces: A Fractal
Analysis of the Kinetics of Regeneration and
Multiple-Analyte Immunoassay (MAIA)
15.1 Introduction 339(2)
15.2 Theory 341(3)
Single-Fractal Analysis 341(2)
15.2.1 Binding Rate Coefficient 341(2)
15.2.2 Dissociation Rate Coefficient 343(1)
Dual-Fractal Analysis 343(19)
15.2.3 Binding Rate Coefficient 343(1)
15.2.4 Dissociation Rate Coefficient 344(1)
15.3 Results 344(13)
15.4 Conclusions 357(2)
References 359(2)
16. Fractal Analysis of Analyte-Receptor 361(28)
Binding and Dissociation Kinetics in
Microcantilever Biosensors
16.1 Introduction 361(1)
16.2 Theory 362(2)
Single-Fractal Analysis 363(1)
16.2.1 Binding Rate Coefficient 363(1)
16.2.2 Dissociation Rate Coefficient 363(1)
Dual-Fractal Analysis 364(1)
16.2.3 Binding Rate Coefficient 364(1)
16.2.4 Dissociation Rate Coefficient 364(1)
16.3 Results 364(19)
16.4 Conclusions 383(2)
References 385(4)
Subject Index 389