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Full Description
Novel and Innovative Drug Delivery Systems to Overcome Chemoresistance in Human Malignancies addresses the critical challenge of cancer chemoresistance, synthesizing insights from cancer biology, molecular biology, biotechnology, and nanotechnology. The book explores the complex mechanisms underlying drug resistance, including alterations in key signaling pathways and the tumor microenvironment's role in cancer cell survival. It highlights advancements in drug delivery technologies, such as nanomedicine and biomimetic strategies, which enhance drug targeting and minimize off-target effects. The integration of techniques like CRISPR-Cas9 and artificial intelligence in developing next-generation therapies is also emphasized.
For an academic audience, this book serves as an essential resource to foster interdisciplinary collaboration in cancer research. It equips researchers, clinicians, and industry professionals with the knowledge needed to navigate the evolving landscape of cancer therapeutics, addressing critical challenges in drug delivery and chemoresistance to improve patient outcomes.
Contents
1. Introduction to Cancer Chemoresistance: Mechanisms and Challenges
2. Impact of Hypoxia, Angiogenesis, and Immune Suppression in Chemoresistance
3. Design and Applications of Nanoparticles, Liposomes, Dendrimers, and Smart Biomaterials-Based Drug Delivery Systems
4. Immunomodulatory Drug Delivery Systems
5. Stimuli-Responsive Drug Delivery Platforms
6. RNA-Based Therapeutics for Overcoming Chemoresistance
7. Drug Repurposing Approaches to Overcome Chemoresistance
8. CRISPR/Cas9 and Gene Editing Approaches as Solutions for Chemoresistance
9. Challenges and Clinical Applications of Novel Drug Delivery Systems
10. Exosome and Extracellular Vesicle-Based Therapeutics
11. Preclinical Models for Evaluating Drug Delivery Systems
12. AI and Machine Learning-Based Drug Design for Overcoming Chemoresistance
