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Full Description
Protein Serine/Threonine Kinases in Neurodegenerative Disorders provides a comprehensive overview of protein serine/threonine kinases (STKs) in health and disease. It also discusses protein kinase inhibitors and their potential role in modulating and treating neurodegenerative diseases. The book begins with an introduction to protein kinases and inhibitors, followed by detailed discussions on different types of kinases, including protein kinase C (PKC), AMP-activated protein kinase (AMPK), Death-associated protein kinase 1 (DAPK1), cyclin-dependent kinases (CDKs), glycogen synthase kinases (GSKs), Rho-associated protein kinase (ROCK), microtubule affinity regulating kinases (MARK), mammalian target of Rapamycin (mTOR), Leucine-rich repeat kinase 2 (LRRK2), PTEN-induced kinase 1 (PINK1), dual-specificity tyrosine phosphorylation-regulated kinase (DYRKs), and their roles in neurodegenerative disease, potential inhibitors, and therapeutic mechanisms.
Protein Serine/Threonine Kinases in Neurodegenerative Disorders features 23 chapters written by renowned experts in kinases field. It explores novel targets modulated by protein kinases, including non-coding RNAs (ncRNAs), mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases, and their roles in neurodegeneration. It also discusses the nexus between glycogen synthase kinases (GSKs) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) and their metabolic regulation role in neurodegeneration. The modulatory effects of protein kinase B (PKB/AKT) pathways in various neurodegenerative disorders, particularly Parkinson's disease, are also examined. The book sheds light on bioactive compounds from natural products that target kinases. The book explains the role of different kinases in various pathogenic pathways and mechanisms involved in neurodegeneration, including regulated cell death, autophagy, synaptic dysfunction, and neuroinflammation. It also discusses splicing kinases in regulating splicing factor phosphorylation and details how aberrant kinase activity leads to splicing defects that contribute to neurodegenerative pathologies. This book emphasizes bridging laboratory research with clinical applications, focusing on translational opportunities. It includes insights from FDA regulatory experts on therapeutic applications and safety considerations of targeting kinases, highlighting the importance of balancing efficacy and safety, particularly in relation to drug-induced liver injury associated with kinase inhibitors. Finally, the book discusses the obstacles and opportunities for the potential repositioning of protein kinase inhibitors in neurodegenerative disorders.
Contents
1. Protein serine/threonine kinases: An overview
2. Protein kinase C (PKC) in Neurodegenerative disorders
3. AMP-activated protein kinase (AMPK) in neurodegenerative disorders
4. Death-associated protein kinase 1 (DAPK1) in neurodegenerative disorders
5. The mitogen-activated protein kinases (MAPKs) activated by tyrosine receptor kinases (Trk receptors for neurotrophin) and their roles in neurodegeneration
6. Cyclin-dependent kinases (CDKs) in neurodegenerative disorders
7. Unlocking the Potential of GSK-3β Inhibitors in Neurodegenerative Disease Prognosis: Insights from Glucagon-like Peptide-1 Receptor Agonist Effects
8. Rho-Associated Coiled-Coil-Containing Protein Kinase (ROCK) in neurodegenerative disorders
9. Microtubule Affinity-Regulating Kinases (MARKs) in neurodegenerative disorders
10. Mammalian target of Rapamycin (mTOR) in neurodegenerative disorders
11. Leucine-Rich Repeat Kinase 2 (LRRK2): A Potential Target in Parkinson's Disease and Beyond
12. PTEN-induced kinase 1 (PINK1) in neurodegenerative disorders
13. Dual-specificity Tyrosine phosphorylation-Regulated Kinase-1A (DYRK1A) in Neurodegenerative disorders
14. AKT pathway as therapeutic target in neurodegenerative diseases: mechanisms and implications
15. Targeting AKT pathways: A potential therapeutic target for Parkinson's disease
16. Non-coding RNAs Regulating Serine/Threonine Kinases in Neurodegeneration
17. Protein serine/threonine signaling pathways: Opportunities and translational perspectives
18. Natural Products in Neurodegenerative Diseases: Role of Serine/Threonine Kinases
19. Targeting autophagy-related serine/threonine kinases to combat neurodegenerative disorders
20. Targeting regulated cell death-related serine/threonine kinases to combat neurodegenerative disorders
21. Splicing Kinases in Neuronal Health and Neurodegeneration
22. Balancing Efficacy and Safety: Protein Kinase Inhibitors and Drug-Induced Liver Injury
23. Targeting serine/threonine kinases: Therapeutic innovations for neurodegenerative disorders
