Full Description
Cellular Therapy for Autoimmune Disease provides a comprehensive exploration of the evolving landscape of cellular therapies for autoimmune diseases. This essential resource addresses the rapid advancements in cell therapies, which have outpaced the availability of integrated, up-to-date resources. By bridging the gap between scientific research and clinical applications, this book offers in-depth insights into mechanisms of action, disease-specific therapeutic strategies, and the latest innovations in clinical and manufacturing considerations for scientists and clinicians.
The book delves into the evolution of the standard of care for autoimmune diseases, transitioning from chronic suppression to targeted replacement or suppression therapies. It covers a wide array of topics, including stem cell transplants, B-cell and plasma cell depletion strategies, and autologous regulatory and effector T-cell approaches. Additionally, it explores myeloid cellular approaches, allogeneic cellular therapies, and viral or nanoparticle-based strategies. Each chapter provides a thorough examination of mechanisms of action, clinical and non-clinical data, and the associated risks and benefits. The book also addresses unique clinical and manufacturing considerations, offering a roadmap for the future state of cellular therapies in autoimmune diseases.
Cellular Therapy for Autoimmune Disease equips professionals with the knowledge necessary to navigate the complexities of cell therapies. By integrating the latest scientific discoveries, clinical breakthroughs, and practical considerations, this book serves as a critical resource for academia, industry, and clinical practice. It highlights the benefits of these therapies, including their potential to transform patient care, and addresses the challenges of safety, efficacy, and scalability. Ultimately, this book aims to accelerate the translation of cellular therapies into clinical practice, fostering innovation and improving outcomes for patients with autoimmune diseases.
Contents
1. How the standard of care for autoimmune diseases has evolved from chronic suppression to that of targeted replacement or suppression
2. Autologous Regulatory T-cell (Treg) approaches for autoimmune disease
3. Autologous Effector T-cell approaches for autoimmune disease. Part I, Antigen Specific Approaches
4. Autologous Effector T-cell approaches for autoimmune disease. Part II, Pan B-cell Depletion Approaches
5. Autologous Effector T-cell approaches for autoimmune disease. Part III, Pan Plasma Cell Depletion Approaches
6. Myeloid Cellular Approaches for Autoimmune Disease
7. Allogeneic Cellular Approaches for Autoimmune Disease
8. Viral or Nanoparticle-Based Approaches for Autoimmune Disease
9. Unique Clinical Considerations for Cellular Therapies for Autoimmune Disease
10. Unique Manufacturing Considerations for Cellular Therapies for Autoimmune Disease
11. Global Perspectives. Regulatory, Ethical, and Cultural Dimensions of Cellular Therapies
12. Future Directions and Challenges for Cellular Therapies in Autoimmune Disease
