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Full Description
An excess of growth hormone (GH) results in accelerated growth and in childhood, the clinical manifestation is gigantism. When GH excess has its onset after epiphyseal fusion at puberty, the overgrowth of soft tissue and bone results in acromegaly. This volume covers various topics related to growth hormone and its associated disorder when there is a GH excess, including their pathophysiology, clinical presentation and diagnosis. The volume includes a total of 8 chapters that provide a comprehensive overview of the synthesis, regulation, and various disorders related to growth hormone, including acromegaly and gigantism. The chapters have been written by experts in the field of pituitary tumors.
Contents
1. Growth hormone: synthesis and regulation
Pedro Iglesias
2. GH and GnRH-gonadotropin secretion
Adriana De Sousa Lages and Valentim Lopes
3. Co-Secreting Pituitary Adenomas in Acromegaly: Classification, Diagnosis, and Treatment Strategies
Betina Biagetti Sr. and Marta Araujo-Castro
4. Growth hormone and glycemic metabolism
Eider Pascual-Corrales
5. Acromegaly: pathophysiology and etiology
Frederic Castinetti
6. Acromegaly: biochemical diagnosis
Luís Miguel Cardoso
7. Acromegaly and clinical manifestations
Rocio Villar-Taibo, Eva Fernández Rodríguez and Ignacio Bernabeu Moron
8. Gigantism
Pedro Marques, Sara Donato and Catarina Regala
9. Acromegaly and genetics
Luís Antonio Castaño
10. Molecular markers of response to medical therapy in acromegaly
Manel Puig
11. Acromegaly and histopathology
Iban Aldecoa
