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Full Description
Direct-Acting Antivirals against Hepatitis C: Current Issues and Future Perspectives is a comprehensive reference that explores Chronic Hepatitis C management. This authoritative reference covers the mechanisms, efficacy, and future potential of Direct-Acting Antivirals (DAAs), offering valuable insights for clinicians, researchers, and students in hepatology and infectious diseases. Structured into three sections, this reference covers a wide range of topics related to DAAs in the management of Hepatitis C. In Section 1, readers will gain a thorough understanding of HCV infection, its clinical significance, and the immune response involved. They will also explore the molecular mechanisms of DAAs and the different classes available. Section 2 focuses on the practical aspects of using DAAs in the treatment of HCV. Readers will discover the clinical efficacy of different DAA regimens, the safety and tolerability considerations, and the additional benefits of DAA treatment beyond virological response. The section also covers current treatment guidelines and individualized approaches for specific patient populations. In Section 3, readers will learn the challenges and future directions in DAA therapy including antiviral resistance in HCV and strategies for managing and overcoming resistance. The book also explores the relationship between DAA therapy and hepatocellular carcinoma, as well as the current limitations and unmet needs in DAA therapy.
Direct-Acting Antivirals against Hepatitis C: Current Issues and Future Perspectives is a comprehensive and indispensable resource for anyone involved in the management of Chronic Hepatitis C. With its in-depth exploration of DAAs, from their molecular mechanisms to their clinical applications and future directions, this book equips clinicians, researchers, and students with the knowledge and insights needed to enhance their practices and contribute to the global fight against HCV infection.
Contents
Section 1. Direct-Acting Antivirals (DAAs) in Hepatitis C
1. Hepatitis C Virus Overview
2. HCV-Host Interactions: Virus specific factors, virus host related determinants, and Intracellular Signaling
3. Introduction to Direct-Acting Antivirals: Mechanisms of Action and different classes
Section 2. Therapeutic Strategies and Clinical Applications of DAAs in managing HCV
4. Clinical Efficacy of different DAAs regimens
5. Safety and tolerability of different DAAs regimens
6. Benefits of treating HCV by DAAs beyond virological response
7. Current landscape and guidelines of DAAs treatment in general population
8. Individualized treatment approaches in various special patient populations
Section 3. Challenges and Future Directions in DAA Therapy
9. Antiviral Resistance in Hepatitis C and DAA Therapy
10. DAA Therapy and hepatocellular carcinoma
11. Limitations and unmet needs in DAAs therapy
12. Emerging Therapeutic Strategies and Future Directions
13. Access to DAAs therapy, and role of DAAs in targeted HCV elimination
