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Full Description
Simulating Protein Folding in Variable Environmental Conditions: Transformation from Globular Proteins to Amyloids delves into the effects of external conditions upon the protein folding process. The book considers how this can lead to amyloid formation and why proteins fold the way they do. It presents the fuzzy oil drop model (FOD-M), which enables the measurements of external factors influencing the folding process and considers changed external conditions as the source for the misfolding process. Sections provide an introduction to amyloid transformation and outline the hypothesis of the model simulation before considering the role of environmental factors, including the water environment and membrane environment.
This book is a useful resource for researchers interested in investigating protein folding across molecular biology, structural biology, biochemistry, computational biology and related fields.
Contents
I. Definition of the amyloid
Irena Roterman and Leszek Konieczny
II. Introduction to the model
Irena Roterman, Katarzyna Stapor, Piotr Fabian, Dawid Du1ak and
Leszek Konieczny
III. Environment-dependent structural factors
Irena Roterman, Leszek Konieczny and Katarzyna Stapor
IV. Three scenarios for amyloid transformation
Irena Roterman, Leszek Konieczny, Piotr Fabian and Katarzyna Stapor
V. Proposed computational procedure for protein and amyloid
structure prediction
Irena Roterman, Leszek Konieczny, Dawid Du1ak and Katarzyna Stapor
VI. Other models
Irena Roterman, Leszek Konieczny, Piotr Fabian and Katarzyna Stapor
