Protein Misfolding and Human Diseases : Deciphering the Central Role of Pathological Aggregation

個数：
  • 予約

Protein Misfolding and Human Diseases : Deciphering the Central Role of Pathological Aggregation

  • 現在予約受付中です。出版後の入荷・発送となります。
    （重要：表示されている発売日は予定となり、発売が延期、中止、生産限定品で商品確保ができないなどの理由により、ご注文をお取消しさせていただく場合がございます。予めご了承ください。）

    ●3Dセキュア導入とクレジットカードによるお支払いについて
  • 【入荷遅延について】
    世界情勢の影響により、海外からお取り寄せとなる洋書・洋古書の入荷が、表示している標準的な納期よりも遅延する場合がございます。
    おそれいりますが、あらかじめご了承くださいますようお願い申し上げます。
  • ◆画像の表紙や帯等は実物とは異なる場合があります。
  • ◆ウェブストアでの洋書販売価格は、弊社店舗等での販売価格とは異なります。
    また、洋書販売価格は、ご注文確定時点での日本円価格となります。
    ご注文確定後に、同じ洋書の販売価格が変動しても、それは反映されません。
  • 製本 Paperback:紙装版/ペーパーバック版／ページ数 400 p.
  • 言語 ENG
  • 商品コード 9780443366369

Full Description

Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book provides a comprehensive overview of pathological protein aggregation, exploring its mechanisms in the context of specific illnesses, including Alzheimer's disease, Parkinson's disease, Huntington's disease, prion diseases, ALS and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. It also features structural insights into protein aggregates from amyloid fibrils to inclusion bodies, and offers therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions. Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. "Protein Misfolding and Human Diseases" serves as an invaluable reference on the intricacies of protein misfolding and its clinical implications. It takes an interdisciplinary approach to the topic, integrating insights across biophysics, cell biology, structural biology, neuroscience and medicine. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders. Pharmaceutical and biotechnology professionals involved in drug discovery and development targeting protein misfolding pathways will also benefit greatly.

Contents

Part I: Fundamentals of protein aggregation
1. Protein aggregation mechanisms

Part II: Protein aggregation in neurodegenerative diseases
2. Protein aggregation in Alzheimer's disease
3. Protein aggregation in Parkinson's disease
4. Protein aggregation in Huntington's disease
5. Protein aggregation in prion diseases
6. Protein aggregation in Amyotrophic Lateral Sclerosis

Part III: Other protein aggregation diseases
7. Systemic amyloidosis
8. Protein aggregation and aging

Part IV: Structural insights and therapeutic Strategies
9. Structural insights into pathological protein aggregates: from amyloid fibrils to inclusion bodies
10. Therapeutic strategies against protein aggregation
11. Recent advances in protein aggregation research and future outlook