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Full Description
Practical Process Research and Development: A Guide for Organic Chemists, Third Edition provides a concise, comprehensive, step-by-step framework to support understanding and implement organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. The book describes the steps taken following synthesis and evaluation to bring key compounds to market in a cost-effective manner. Through a hands-on, step-by-step approach to solving process development problems, including route, reagent, and solvent selection, optimizing catalytic reactions, chiral syntheses, and green chemistry, this book helps organic, medicinal, pharmaceutical, and chemical process development chemists as well as chemical engineers with research and development initiatives.
In addition, it is well suited for beginners at upper undergraduate and graduate student level and early career researchers who need accessible insights into industrial process R&D.
Contents
1. Introduction
2. Safety Reactions
3. Route selection
4. Reagent selection
5. Solvent selection
6. Practical considerations for scale-up
7. In-process controls and reaction duration
8. Process optimization by minimizing impurities
9. Work-up conditions
10. Purification, crystallization and isolation
11. Final product form and impurities
12. Continuous operations
13. Scale-up concerns, validation, and process implementation
14. Trouble-shooting
