Full Description
Roles of the Cerebellum in Motor Control: Foundations, Experimental Approaches and Clinical Applications is a groundbreaking comprehensive reference of the intricate relationship between the cerebellum and motor function. Spanning five thorough sections, this book examines experimental approaches, from single neurons to networks, unraveling the mysteries of olivocerebellar somatotopy, motor prediction, and the cellular basis of motor learning. With chapters dedicated to neuroimaging, physiology, and pathophysiology, users will gain insight into the cerebellum's role in conditions such as tremor, dystonia, and Parkinson's disease. From wearable sensors to digital gait biomarkers, various chapters offer a cutting-edge look at sensor technology and its application in assessing cerebellar function and rehabilitation. The book concludes with a discussion on research and clinical implications, providing a roadmap for translating laboratory findings into effective therapeutic strategies, making it an indispensable resource for researchers, clinicians, and students alike.
Contents
SECTION 1. Experimental approaches: from single neurons to networks
1. The olivocerebellar somatotopy
2. Cerebellum-brainstem loops
3. Fastigial nuclei: inputs/outputs
4. Complex spikes
5. Memory of motor learning
6. Motor prediction and feedback in Purkinje cell activity.
7. synchrony in cerebellar cortico-nuclear interactions
8. LTD
9. Predictive computations
10. Cellular imaging of cerebello-cerebral interactions
11. Intermodular integration in the cerebellar cortex for motor control
12. Cerebellar contribution to the development of sensorimotor circuits
13. Error processing in the cerebellar cortex
14. Mechanistic and Functional Diversity in Cerebello - Cerebral Coupling
15. Cerebellum-basal ganglia interactions
SECTION 2. From sensors to digital assessment of motion
16. digital gait biomarkers / wearables / cerebellar gait / rehab
17. Wearable sensors for upper limbs
18. Camera-based analysis
19. Gait
20. Machine learning
SECTION 3. Neuroimaging
21. Imaging of the motor cerebellum / circuits
22. Cerebellum and tremor: neuroimaging aspects
23. Functional connectivity
24. The cerebellar connectome
25. Structure-function relations in dystonia
26. Functional organization and perturbation of the cerebellum
SECTION 4. Physiology and pathophysiology of motion
27. Cerebellar control of timing and eye saccade
28. Cerebello-cerebral circuit in motor control and preparation
29. Sensorimotor integration of proprioception
30. Cerebellum in reaching movement
31. Cortico-cerebellar loops in reaching movement
32. timing behind motor control
33. Neurophysiology of cerebellar motor control in NHP
34. cerebellar control of locomotion
35. Occulomotor reflexes
36. Cerebellar cortico-nuclear interactions in eyeblink conditioning
37. Neurophysiology of cerebellum in tremor
38. Cerebellum and Parkinson's disease
SECTION 5. Research and clinical implications: from the lab to the rehabilitation
39. Cerebellar dysfunction and rehabilitation
40. Cerebellar-based therapies of motor dysfunction
41. cerebellum and fatigue
42. non-invasive cerebellar stimulation / rehab
43. Cerebellar reserve
