Full Description
Pharmacogenomics: From Research to Clinical Implementation is a comprehensive guide that explores the integration of pharmacogenomics into personalized medicine, offering up-to-date knowledge on how genetic variation affects drug response in diverse therapeutic areas such as cardiology, oncology, psychiatry, and more. Pharmacogenomics: From Research to Clinical Implementation starts with foundational principles, including pharmacodynamics and pharmacokinetics. It then progresses to advanced topics, including the pharmacogenomics of infectious diseases and organ transplantation, providing readers with both the historical context and current advances in the field. Each chapter methodically discusses the application of pharmacogenomics in clinical settings, supported by methods, translational tools, and case studies, ensuring that students, healthcare professionals, and researchers gain practical insights into tailoring drug therapy to genetic profiles. This book also addresses public health perspectives, including ethical, legal, and economic aspects, making it an indispensable resource for anyone looking to deepen their understanding of pharmacogenomics and its essential role in advancing personalized medicine. Designed to cater for a broad audience, including students, biomedical scientists, and clinicians, Pharmacogenomics not only serves as an educational tool but also as a bridge to clinical practice, emphasizing how pharmacogenetic knowledge can lead to more effective and safer drug therapies.
Contents
1. Principles and history of Pharmacogenomics: Pharmacodynamics, pharmacokinetics and Pharmacogenomics
2. Methods in pharmacogenomics
3. Translational tools and databases in pharmacogenomics PHARMACOGENOMICS AND CLINICAL CARE
4. Pharmacogenomics in Cardiovascular Diseases
5. Pharmacogenomics in Cancer Therapeutics
6. Pharmacogenomics of Psychiatric Drugs
7. Pharmacogenomics in Infectious Diseases
8. Pharmacogenomics in organ transplantation
9. Epigenomics, metabolomics, and Other Omics in Drug Response
10. Population pharmacogenomics
11. Pharmacogenomics Consortia PUBLIC HEALTH PHARMACOGENOMICS
12. Ethical, legal, and regulatory issues associated with Pharmacogenomics
13. PGx reporting and portability of results.
14. Cost-effectiveness, pricing and reimbursement of genome-guided treatment
15. Raising pharmacogenomics awareness of the general public and healthcare professionals.
