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Full Description
Bioreactors for Health and Sustainability describes the basic concepts of chemical and biochemical kinetics, chemical reaction engineering, reactors design, ideal reactors, homogeneous and heterogeneous reactors. The book brings together in a single source the most significant types of reactors that use molecular (enzymes) and cells biocatalysts for biological applications, which range from enzyme reactors, microbial reactors, plant cell culture and reactors, photobioreactors, cell reactors, reactors for stem cell culture, reactors for tissue and organ engineering, microbioreactors, reactors for cellular agriculture products, to bioreactors for waste-water treatment. It elaborates on bioreactors from molecular level enzymes, to microbial, plant, animal and human cells and tissue and organs, and provides sustainable applications in industrial, environmental and health sectors. As such the book bridges the gap between the Engineering Sciences and Technology and Health Sciences areas. Bioreactors for Health and Sustainability brings a novel contribution to biotechnology that is based on the upstream of a biological process, which makes it of broad interest for professionals, researchers, and students in biological/biochemical engineering and bioengineering.
Contents
1. Chemical and Biochemical Kinetics Basic concepts of chemical kinetics, enzyme kinetics and cell culture growth
2. Chemical Reactors Basic concepts of chemical reaction engineering and reactors design, ideal reactors, homogeneous and heterogeneous reactors. Type of reactors: BSTR, PFR and CSTR. Project design of real reactors, mass transfer and hydrodynamics aspects, axial dispersion in column reactors.
3. Enzyme Reactors Enzyme immobilization, immobilized enzyme kinetics, mass transfer effects, BSTR, Packed and Fluidized Bed Reactors. Intracellular enzyme reactors, Immobilized Death Cell Reactors. Multienzyme reactors
4. Microbial Reactors Microbial cell growth kinetics, fermentation, oxygen transfer coefficient, oxygen uptake rate, cell growth rate, specific cell productivity, growth-associated and non-growth linked products. Sterilization. Cultivation modes: Batch, Fed-batch and Continuous. Bubble column and air-lift reactors are described. Applications to pharmaceutical and biotechnology industry are analyzed.
5. Plant Cell Culture and Reactors Plant cell and tissue culture to produce commercially valuable secondary metabolites. Effects of mixing, oxygen transfer, cell aggregation and adhesion are analyzed as well as various bioreactors, according to the dynamics of growth and product formation. Criteria for choosing a bioreactor type for optimal growth and metabolite production are also discussed. Bioreactors for plant micropropagation.
6. Photobioreactors Cultivation systems for growing photoautotrophic organisms, namely microalgae and cyanobacteria, for production of bioactive compounds, biofuels, pharmaceuticals, and other industrial applications. Description of closed systems using artificial light sources. Open systems using solar light to facilitate photosynthesis.
7. Animal Cell Reactors for Biopharmaceuticals and Vaccines (TBC) Animal Cell characteristics, culture media selection, growth kinetics. Selection of immortalized cell lines. Type of bioreactors. Biopharmaceuticals, vaccine production and gene therapy.
8. Reactors for Stem Cell Culture Definition of stem cells, different types of stem cells, pluripotent and embryonic and adult stem cells. Types of stem cells (hematopoietic, mesenchymal/stromal, neural osteochondral, etc..). Type of bioreactor for stem cells expansion and differentiation. Perfusion bioreactors.
9. Reactors for Tissue and Organ Engineering 3D-constructs, scaffolds for stem cell expansion and differentiation and tissues. Mass transfer issues, oxygen, and nutrients limitations. Shear stress, mechanical and electric stimuli, mechano-transduction and cellular signaling, stretch/compression. Decellularization, cell seeding, organ engineering. Bioartificial organs.
10. Microbioreactors Introduction of MicroBioReactors (MBR) from microfluidics (microliter scale) and simple miniaturized enzyme and cell cultivations microdevices (i.e., in the milliliter scale) to highly complex and automated small-scale microreactors for early-stage bioprocess development, fermentation, drug screening, toxicology tests and tissue engineering
11. Reactors for Cellular Agriculture Products History of cultured meat, cell sources and methods used for the purpose of in vitro meat production, with particular focus on the role of bioreactors and edible scaffolds. Type of bioreactors, scaffolds and microcarriers for in vitro meat and fish production.
12. Bioreactors for Waste-Water Treatment Biological wastewater treatment process. Stirred bioreactors for aerobic and anaerobic treatment. Packed and fluidized bed biofilm and slurry reactors
